| 王雅萍,徐友娣,汤琳琳,雷 磊,谷茂红.尿酸及NLRP3炎症小体与妊娠期高血压的相关性分析[J].,2020,(1):85-88 |
| 尿酸及NLRP3炎症小体与妊娠期高血压的相关性分析 |
| Analysis of the Correlation of Uric Acid and NLRP3 Inflammasome with Hypertensive Disorder Complicating Pregnancy |
| 投稿时间：2019-06-15 修订日期：2019-07-11 |
| DOI：10.13241/j.cnki.pmb.2020.01.018 |
| 中文关键词: 妊娠期高血压 尿酸 NLRP3炎症小体 相关性 |
| 英文关键词: Hypertensive disorder complicating pregnancy Uric acid NLRP3 inflammasome Correlation |
| 基金项目:江苏省卫计委科研基金项目(F-201661 |
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| 中文摘要: |
| 摘要 目的：观察妊娠期高血压孕产妇尿酸与Nod样受体蛋白3(nucleotide-binding oligomerization domain- leucine-rich repeats containing pyrin domain 3，NLRP3)炎症小体表达，分析二者与疾病的相关性，为妊娠期高血压的诊断提供参考。方法：选择我院产科2016年3月至2019年3月常规产检并诊断为妊娠期高血压孕产妇200例为研究组，参照《妊娠期高血压诊治指南(2015)》中各妊娠期高血压分级标准将研究组200例孕产妇分为妊娠期高血压组(86例)、轻度子痫前期组(57例)、重度子痫前期组(57例)，另选择同期在我院接受常规产检的200例健康孕产妇作为对照组。检测并比较4组孕产妇血清尿酸、NLRP3炎症小体mRNA及NLRP3蛋白表达，经双变量Spearman相关性分析检验各指标与疾病的相关性。结果：4组孕产妇年龄、孕周、孕次、产次等一般资料比较差异无统计学意义(P＞0.05)；重度子痫前期组血清尿酸水平、NLRP3 mRNA及NLRP3蛋白表达最高，后由高至低依次为轻度子痫前期组、妊娠期高血压组、对照组，组间两两比较差异均有统计学意义(P＜0.05)；经双变量Spearman相关性分析检验证实，血清尿酸、NLRP3 mRNA表达和蛋白表达与妊娠期高血压发生发展均呈正相关(r=0.709、0.833、0.693，P均＜0.001)。结论：妊娠期高血压孕产妇血清尿酸与NLRP3炎症小体水平上调，且随着孕产妇病情的加重升高，可考虑将其作为妊娠期高血压疾病早期诊断及预后评估的血清学参考指标。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the levels of uric acid and nucleotide-binding oligomerization domain- leucine-rich repeats containing pyrin domain 3 (NLRP3) inflammasome expression in pregnant women with hypertensive disorder complicating pregnancy (HDCP) and their correlation with HDCP. Methods: 200 pregnant women who received routine antenatal examination and were diagnosed with HDCP in the department of obstetrics from March 2016 to March 2019 were selected as research group. According to the grading standard referring to the Guidelines for the Diagnosis and Treatment of Hypertensive Disorder Complicating Pregnancy (2015), 200 pregnant women in research group were divided into the gestational hypertension group (86 cases), mild pre-eclampsia group (57 cases), and severe pre-eclampsia group (57 cases). 200 healthy pregnant women who received routine antenatal examination were selected as control group. The serum uric acid, NLRP3 inflammasome mRNA, NLRP3 protein expression were compared among the four groups. The correlation between the indicators and the disease was examined by bivariate Spearman correlation analysis. Results: There was no statistical difference in the maternal age, gestational weeks, gravidity, parity among the four groups (P>0.05); Among four groups, the serum uric acid level, NLRP3 mRNA expression, NLRP3 protein expression in severe pre-eclampsia group were the highest, followed by mild pre-eclampsia group, gestational hypertension group and control group, and the difference was statistically significant (P<0.05); Bivariate Spearman correlation analysis confirmed that the serum uric acid, NLRP3 mRNA expression, NLRP3 protein expression had positive correlation with the occurrence and development of HDCP (r=0.709, 0.833, 0.693, P<0.001). Conclusion: The levels of uric acid and NLRP3 inflammasome in pregnant women with HDCP increase. With the aggravation of maternal conditions, uric acid and NLRP3 inflammasome can be used as serological indicators for early diagnosis and prognostic evaluation of HDCP. |
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