| 杨丹平,郑 勇,李秋晨,丁 新,童娟娟,陈卫刚.食管鳞状细胞癌中SSBP1和mtTFA的表达及其临床病理意义[J].,2020,(1):118-122 |
| 食管鳞状细胞癌中SSBP1和mtTFA的表达及其临床病理意义 |
| Expression and Clinicopathological Significances of SSBP1 and mtTFA in the Esophageal Squamous Cell Carcinoma |
| 投稿时间：2019-04-28 修订日期：2019-05-23 |
| DOI：10.13241/j.cnki.pmb.2020.01.026 |
| 中文关键词: 食管鳞状细胞癌 线粒体单链DNA结合蛋白 线粒体转录因子A |
| 英文关键词: Esophageal squamous cell carcinoma Mitochondrial single-stranded DNA-binding protein Mitochondrial transcription factor A |
| 基金项目:新疆维吾尔自治区地区科学基金项目(81260362) |
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| 中文摘要: |
| 摘要 目的：探讨食管鳞状细胞癌(Esophageal squamous cell carcinoma，ESCC)组织中线粒体单链DNA结合蛋白(single-strand DNA-binding protein 1，SSBP1)与线粒体转录因子A(mitochondrial transcription factor A，mtTFA)的表达及其临床病理意义。方法：采用免疫组化染色技术检测40例食管鳞状细胞癌组织与20例正常食管组织中SSBP1与mtTFA蛋白的表达，并分析其与食管鳞状细胞癌临床病理特征的相关性。结果：食管鳞状细胞癌组织中SSBP1和mtTFA的表达阳性率均明显高于正常食管组织( x2＝9.909，P＝0.002； x2＝23.177，P＝0.000)。SSBP1、mtTFA蛋白的表达与食管鳞状细胞癌的临床分期( x2＝6.506，P＝0.039； x2＝7.535，P＝0.023)、淋巴结转移( x2＝7.305，P＝0.007； x2＝4.815，P＝0.028)显著相关；mtTFA蛋白的表达与食管鳞状细胞癌的浸润深度有关( x2＝8.541，P＝0.014)，SSBP1的表达与浸润深度无关( x2＝5.695，P＝0.058)。食管鳞状细胞癌组织中SSBP1与mtTFA的表达呈正相关(r＝0.392，P＝0.012)。结论：食管鳞状细胞癌组织中SSBP1和mtTFA蛋白均呈表达上调，二者可能协同作用参与食管鳞癌的发生、发展。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the expression and clinicopathological significances of mitochondrial DNA binding protein 1 (SSBP1) and mitochondrial transcription factor A (mtTFA) in the esophageal squamous cell carcinoma (ESCC) tissues. Methods: Immunohistochemical staining was used to detect the expression of SSBP1 and mt-TFA protein in 40 cases of esophageal squamous cell carcinoma and 20 normal esophageal tissue. Their correlation with the clinicopathological features of ESCC were analyzed. Results: The positive rates of SSBP1 and mtTFA in the ESCC were significantly higher than those in the normal esophageal tissues ( x2＝9.909, P＝0.002; x2＝23.177, P＝0.000). The expression of SSBP1, mtTFA protein were significantly related to the clinical stage of esophageal squamous cell carcinoma ( x2＝6.506, P＝0.039; x2＝7.535, P＝0.023), lymph node metastasis ( x2＝7.305, P＝0.007; x2＝4.815, P＝0.028). The expression of mtTFA protein was related to the depth of invasion of esophageal squamous cell carcinoma ( x2＝8.541, P＝0.014). The expression of SSBP1 showed no relationship with the depth of invasion ( x2＝5.695, P＝0.058). There was a positive correlation between SSBP1 and mtTFA expression in esophageal squamous cell carcinoma (r＝0.392, P＝0.012). Conclusion: SSBP1 and mtTFA proteins are up-regulated in the esophageal squamous cell carcinoma, and they may participate in the development and progression of esophageal squamous cell carcinoma. |
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