| 代 菁,解 红,姚 峰,任浩进,龚 凡,朱晓刚.NT-proBNP、BNP及hs-CRP在老年急性非ST段抬高型心肌梗死患者血浆中的表达及临床意义[J].,2020,(6):1134-1137 |
| NT-proBNP、BNP及hs-CRP在老年急性非ST段抬高型心肌梗死患者血浆中的表达及临床意义 |
| Expression and Clinical Significance of NT-proBNP, BNP and hs-CRP in Plasma of Elderly Patients with Acute Non-ST-segment Elevation Myocardial Infarction |
| 投稿时间：2019-07-07 修订日期：2019-07-31 |
| DOI：10.13241/j.cnki.pmb.2020.06.030 |
| 中文关键词: 老年 急性非ST段抬高型心肌梗死 N末端前体脑钠肽 脑钠肽 超敏C反应蛋白 |
| 英文关键词: Elderly Acute non-ST-segment elevation myocardial infarction N terminal precursor brain natriuretic peptide Brain natriuretic peptide High sensitivity C- reactive protein |
| 基金项目:湖北省医学科研计划项目（HBYX16D01） |
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| 中文摘要: |
| 摘要 目的：探讨N末端前体脑钠肽（NT-proBNP）、脑钠肽（BNP）及超敏C-反应蛋白（hs-CRP）在老年急性非ST段抬高型心肌梗死患者血浆中的表达及临床意义。方法：选择2015年2月~2018年7月在我院进行诊治的老年急性非ST段抬高型心肌梗死患者200例为观察组，选择同期在我院进行诊治的非冠脉综合征患者100例为对照组。入院后次日检测所有患者的血浆中的NT-proBNP、BNP及hs-CRP等指标的水平，并对比两组患者以及观察组中不同血管病变支数患者上述指标水平。两组患者均随访6个月，观察心血管不良事件的发生率。结果：观察组患者的NT-proBNP、BNP及hs-CRP水平均显著高于对照组，组间比较差异有统计学意义（P<0.05）。观察组内单支血管病变、双支血管病变、三支血管病变患者间NT-proBNP、BNP及hs-CRP水平比较差异有统计学意义（P<0.05），各项指标水平随着血管病变支数增加而升高（P<0.05）。观察组在出院后为期6个月随访期间心血管不良事件发生率为16.50%，高于对照组心血管不良事件发生率为6.00%，组间比较差异有统计学意义（P<0.05）。患者冠脉血管病变支数与血浆NT-proBNP、BNP及hs-CRP水平间呈正相关（P<0.05）。结论：血浆NT-proBNP、BNP及hs-CRP水平在老年急性非ST段抬高型心肌梗死患者中显著升高，且随着患者血管病变程度的增加而升高，对患者预后心血管不良事件判断有较好的预测作用。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the expression and clinical significance of N terminal precursor brain natriuretic peptide (NT-proBNP), brain natriuretic peptide (BNP) and high sensitivity C- reactive protein (hs-CRP) in plasma of elderly patients with acute non-ST-segment elevation myocardial infarction. Methods: 200 elderly patients with acute non-ST-segment elevation myocardial infarction treated in our hospital from February 2015 to July 2018 were selected as observation group, 100 patients with non-coronary syndrome who were diagnosed and treated in our hospital at the same time were selected as the control group. The levels of NT-proBNP, BNP and hs-CRP in plasma of all patients were detected the next day after admission. The above indexes were compared between the two groups and the observation group with different vessel lesion branches. Both groups were followed up for six months to observe the incidence of cardiovascular adverse events. Results: The levels of NT-proBNP, BNP and hs-CRP in the observation group were significantly higher than those in the control group, and there were significant difference between the two groups (P<0.05). There were significant differences in NT-proBNP, BNP and hs-CRP levels among patients with single vessel disease, double vessel disease and three vessel disease in the observation group(P<0.05), and the levels of each index increased with the increase of vessel disease branches (P<0.05). The incidence of cardiovascular adverse events in the observation group were 16.50% during the six months follow up period after discharge, which were higher than 6.00% in the control group, there were significant difference between the two groups (P<0.05). The number of coronary artery lesion branches were positively correlated with plasma NT-proBNP, BNP and hs-CRP levels (P<0.05). Conclusion: The levels of NT-proBNP, BNP and hs-CRP in plasma are significantly increased in elderly patients with acute non-ST-segment elevation myocardial infarction, and increased with the increase of the degree of vascular lesions, which has a good predictive effect on the prognosis of cardiovascular adverse events. |
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