| 郭 茹,蔡宝云,黄学锐,王 敬,杜亚东.肺结核患者治愈后复发危险因素分析及耐药状况调查[J].,2020,(9):1699-1702 |
| 肺结核患者治愈后复发危险因素分析及耐药状况调查 |
| Risk Factors Analysis and Drug Resistance Status Investigation of Pulmonary Tuberculosis Patients after Cure |
| 投稿时间：2019-12-06 修订日期：2019-12-30 |
| DOI：10.13241/j.cnki.pmb.2020.09.020 |
| 中文关键词: 肺结核 复发 危险因素，耐药 多因素Logistic回归分析 |
| 英文关键词: Tuberculosis Recurrence Risk factors Drug resistance status Multivariate Logistic regression analysis |
| 基金项目:国家"十三五"传染病科技重大专项（2018ZX10725-509）；"十三五"重大新药创制科技重大专项（2017ZX09304009） |
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| 中文摘要: |
| 摘要 目的：研究肺结核患者治愈后复发危险因素以及耐药状况。方法：回顾性分析我院于2015年5月～2017年12月期间收治的1000例肺结核患者的临床资料。对所有患者均进行为期2年的随访观察，统计复发情况。将所有患者按照治愈后复发与否分成复发组58例以及无复发组942例，比较两组患者基线资料情况，包括年龄、性别、耐药、吸烟、职业类型、居住情况以及空洞，并对影响肺结核患者治愈后复发的因素作多因素Logistic回归分析，对所有治愈后复发患者的耐药情况进行检验，分析其耐单药、耐2药、耐3药、耐4药人数的占比情况。结果：1000例肺结核患者治愈后复发58例，复发率为5.80%。肺结核患者治愈后是否复发与性别、年龄、吸烟无关（P>0.05），复发组耐药、体力型工作、流动人口、空洞患者的比例高于未复发组（P<0.05）。经多因素Logistic回归分析可得：耐药、体力型工作、流动人口、空洞均是肺结核患者治愈后复发的独立危险因素。58例患者中发生耐药例数27例，耐药率为46.55%；其中耐单药、耐2药、耐3药、耐4药人数分别为8、10、7、2例，相应占比为13.79%、17.24%、12.07%、3.45%。结论：肺结核患者治愈后复发的风险较高，尤其应注意耐药、体力型工作、流动人口、空洞的患者，以降低疾病复发，且肺结核复发患者的耐药情况不容乐观。 |
| 英文摘要: |
| ABSTRACT Objective: To study the risk factors and drug resistance of pulmonary tuberculosis patients after cure. Methods: A retrospective analysis was performed on 1000 tuberculosis patients who were admitted to our hospital from May 2015 to December 2017. All patients were followed up for a period of 2 years, and the recurrence was counted. All the patients were divided into the relapse group 58 cases and the non-relapse group 942 cases according to whether they had relapsed or not after cure. The baseline data of the two groups were compared, mainly including age, gender, drug resistance, smoking, occupation type, residence status and void. The factors influencing the recurrence of pulmonary tuberculosis after cure were analyzed by multivariate Logistic regression analysis. The drug resistance of all patients with relapse after cure were tested, and the proportion of patients with single drug resistance, 2 drugs resistance, 3 drugs resistance and 4 drugs resistance were analyzed. Results: 58 cases recurrence after the cure of 1000 cases of tuberculosis, the recurrence rate was 5.80%. There was no correlation between relapse and gender, age and smoking (P>0.05). The proportion of drug resistance, physical work, floating population and cavity patients in relapse group were higher than those in non- relapse group (P<0.05). According to the multivariate logistic regression analysis, drug resistance, physical work, floating population and air pollution were the independent risk factors for relapse of pulmonary tuberculosis patients. Among the 58 patients, 27 were resistant, the resistant rate was 46.55%. Among them, 8, 10, 7 and 2 cases were resistant to single drug, 2, 3 and 4 respectively, accounting for 13.79%, 17.24%, 12.07% and 3.45% respectively. Conclusion: Tuberculosis patients have a higher risk of recurrence after cure, especially should pay attention to drug resistance, physical work, the floating population, cavity patients, in order to reduce the recurrence of disease. And the tuberculosis relapses patient's resistance condition is not optimistic. |
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