| 弥 娜,王玉静,叶丽辉,谢晓莉,张国庆.超声心动图与血浆BNP、和肽素、hs-CRP对慢性心力衰竭患者心功能的评估价值分析[J].,2020,(9):1703-1706 |
| 超声心动图与血浆BNP、和肽素、hs-CRP对慢性心力衰竭患者心功能的评估价值分析 |
| Value of Echocardiography, BNP, Peptide Hormones and hs-CRP in the Evaluation of Heart Function in Patients with Chronic Heart Failure |
| 投稿时间：2019-12-08 修订日期：2019-12-31 |
| DOI：10.13241/j.cnki.pmb.2020.09.021 |
| 中文关键词: 慢性心力衰竭 超声心动图 脑钠肽 和肽素 超敏C反应蛋白 |
| 英文关键词: Chronic heart failure Echocardiography Brain natriuretic peptide Peptide hormones Hypersensitive C-reactive protein |
| 基金项目:兰州军区科研卫生项目(CLZ15JB0416) |
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| 中文摘要: |
| 摘要 目的：研究超声心动图与血浆脑钠肽（BNP）、和肽素及超敏C反应蛋白（hs-CRP）对慢性心力衰竭（CHF）患者心功能的评估价值。方法：将我院从2017年3月～2020年3月收治的100例CHF患者纳入研究。将其按照美国纽约心脏病协会（NYHA）分级标准分成Ⅰ级33例，Ⅱ级21例，Ⅲ级25例，Ⅳ级21例。对所有患者均进行超声心动图检查，分析相关参数的差异。检测并对比所有患者血浆BNP、和肽素以及hs-CRP水平。采用Pearson相关性分析超声心动图相关参数与血浆BNP、和肽素及hs-CRP水平的关系。结果：心功能分级Ⅰ～Ⅳ级患者的左室射血分数（LVEF）呈逐渐降低趋势，而左房内径（LAD）及左室舒张末期内径（LVEDD）均呈逐渐升高趋势（P＜0.05），血浆BNP、和肽素及hs-CRP水平均呈逐渐升高趋势（P＜0.05）。经Pearson相关性分析可得：CHF患者LVEF与血浆BNP、和肽素及hs-CRP均呈负相关（r=-0.621、-0.534、-0.635，P＜0.05），而LAD、LVEDD与血浆BNP、和肽素及hs-CRP均呈正相关（r=0.582、0.602、0.511，r=0.547、0.592、0.615，P＜0.05）。结论：超声心动图及血浆BNP、和肽素、hs-CRP用于评估CHF患者心功能均效果显著，且联合检测具有协同互补的作用，实现对CHF患者病情严重程度更为精准的评估。 |
| 英文摘要: |
| ABSTRACT Objective: To study the value of echocardiography, plasma brain natriuretic peptide (BNP), peptide hormones and hypersensitive C-reactive protein (hs-CRP) in the evaluation of heart function in patients with chronic heart failure (CHF). Methods: 100 patients with CHF who were admitted to our hospital from March 2017 to March 2020 were included in the study. According to the American heart association of New York(NYHA) classification standard, they were divided into 33 cases of grade I, 21 cases of grade II, 25 cases of grade III, 21 cases of grade IV. Echocardiography was performed on all subjects, the differences in relevant parameter levels were analyzed. Plasma BNP, peptide and hs-CRP levels were measured and compared in all patients. Pearsn correlation was used to analyze the correlation parameters of echocardiography with plasma BNP, peptide and hs-CRP levels. Results: The cardiac function class Ⅰ ~ Ⅳ in patients with left ventricular ejection fraction (LVEF) showed a trend of gradually reduce, while the left atrial diameter (LAD) and left ventricular end-diastolic diameter (LVEDD) showed a trend of increased (P<0.05), plasma BNP, and peptide hormones and hs-CRP levels showed a trend of increased (P<0.05). According to Pearson correlation analysis, LVEF in patients with CHF were negatively correlated with plasma BNP, peptide hormones and hs-CRP (r=-0.621, -0.534, -0.635, P<0.05), while LAD and LVEDD were positively correlated with plasma BNP, peptide hormones and hs-CRP (r=0.582, 0.602, 0.511, r=0.547, 0.592, 0.615, P<0.05). Conclusion: Echocardiography, plasma BNP, peptide hormones and hs-CRP were all effective in evaluating cardiac function in patients with CHF, and the combined detection had a synergistic and complementary effect, and it can achieve a more accurate assessment of the severity of CHF. |
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