| 徐 寅,司空银河,王 宁,王 浩,许 琳.胆管癌组织白介素-6、环氧合酶-2和血管内皮生长因子的表达及临床意义[J].,2020,(11):2098-2101 |
| 胆管癌组织白介素-6、环氧合酶-2和血管内皮生长因子的表达及临床意义 |
| Expression and Clinical Significance of IL-6, COX-2 and VEGF in Cholangiocarcinoma |
| 投稿时间：2019-11-07 修订日期：2019-11-30 |
| DOI：10.13241/j.cnki.pmb.2020.11.020 |
| 中文关键词: 胆管癌 白介素-6 血管内皮生长因子 环氧合酶-2 免疫组织化学 |
| 英文关键词: Cholangiocarcinoma Interleukin-6 Vascular endothelial growth factor Cyclooxygenase-2 Immunohistochemical |
| 基金项目:山东省医药卫生科技发展计划项目（2015WS1129） |
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| 中文摘要: |
| 摘要 目的：探讨胆管癌组织白介素-6（IL-6）、环氧合酶-2（COX-2） 和血管内皮生长因子（VEGF）的表达及临床意义。方法：将手术切除并经病理诊断确诊的胆管癌石蜡包埋标本80例纳为胆管癌组，另取癌旁正常胆管组织作为对照组，采用免疫组织化学SP法检测两组组织中IL-6、COX-2、VEGF的表达情况并做比较，分析胆管癌组织中 VEGF、COX-2、IL-6阳性表达与临床病理特征关系，采用Spearman等级相关分析胆管癌组织中VEGF、COX-2、IL-6表达的相关性。结果：胆管癌组的VEGF、COX-2、IL-6阳性表达率均显著高于对照组，组间比较差异有统计学意义（P<0.05）。胆管癌组织中VEGF、COX-2、IL-6阳性表达率与有无淋巴结转移、TNM分期、分化程度有关（P<0.05），而与性别、年龄、肿瘤直径无关（P>0.05），其中有淋巴结转移、TNM分期Ⅲ～Ⅳ期、低分化程度的胆管癌患者的VEGF、COX-2、IL-6阳性表达率高于无淋巴结转移、TNM分期Ⅰ～Ⅱ期、中高分化程度的胆管癌患者（P<0.05）。Spearman等级相关分析显示，胆管癌组织中 VEGF与COX-2、IL-6呈正相关（P<0.05），COX-2与IL-6也呈正相关（P<0.05）。结论：胆管癌组织IL-6、COX-2、VEGF均呈现高表达，并与胆管癌的生长、转移密切相关，检测IL-6、COX-2和VEGF有助于判断胆管癌疾病进展。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the expression and clinical significance of interleukin-6 (IL-6), cyclooxygenase-2(COX-2) and vascular endothelial growth factor (VEGF) in cholangiocarcinoma. Methods: 80 patients with paraffin-embedded specimens of cholangiocarcinoma surgically resected and pathologically diagnosed were selected as cholangiocarcinoma group, and the normal bile duct tissues adjacent to cancer as control group. The expressions of IL-6, COX-2 and VEGF in the two groups were detected by immunohistochemical SP method and compared. The positive expressions of VEGF, COX-2 and IL-6 in cholangiocarcinoma tissues were analyzed and compared with clinical data. Spearman grade correlation was used to analyze the correlation of expression of VEGF, COX-2 and IL-6 in cholangiocarcinoma. Results: The positive expression rates of VEGF, COX-2 and IL-6 in cholangiocarcinoma group were significantly higher than those in control group, and there was significant difference between the two groups (P<0.05). The positive expression rates of VEGF, COX-2 and IL-6 in cholangiocarcinoma tissues were correlated with lymph node metastasis, TNM stage and differentiation degree (P<0.05), but not with sex, age and tumor diameter (P>0.05). The positive expression rates of VEGF, COX-2 and IL-6 in cholangiocarcinoma tissues were correlated with lymph node metastasis, TNM stage and differentiation degree(P<0.05). Spearman grade correlation analysis showed that there was a positive correlation between the positive expression rate of VEGF and COX-2, IL-6 in cholangiocarcinoma (P<0.05), and the positive expression rate of COX-2 and IL-6 in cholangiocarcinoma (P<0.05). Conclusion: The IL-6, COX-2 and VEGF are highly express in cholangiocarcinoma tissues, which are closely related to the growth and metastasis of cholangiocarcinoma. Detection of IL-6, COX-2 and VEGF is helpful in judging the progress of cholangiocarcinoma. |
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