| 张 正,吴津民,周振章,陈 磊,刘 勇.功能性核磁共振成像技术对原发性三叉神经痛患者脑功能的评估价值及血清IL-1β、TNF-α检测的临床意义[J].,2020,(11):2126-2130 |
| 功能性核磁共振成像技术对原发性三叉神经痛患者脑功能的评估价值及血清IL-1β、TNF-α检测的临床意义 |
| The Evaluation Value of Functional Magnetic Resonance Imaging in Brain Function of Patients with Idiopathic Trigeminal Neuralgia and the Clinical Significance of Serum IL-1β and TNF-α Detection |
| 投稿时间：2019-10-06 修订日期：2019-10-28 |
| DOI：10.13241/j.cnki.pmb.2020.11.027 |
| 中文关键词: 原发性三叉神经痛 功能性核磁共振成像技术 脑功能评估 白细胞介素-1β 肿瘤坏死因子-α |
| 英文关键词: Idiopathic trigeminal neuralgia Functional magnetic resonance imaging Evaluation of brain function Interleukin-1 β Tumor necrosis factor-α |
| 基金项目:安徽省科技计划项目（14070040361） |
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| 中文摘要: |
| 摘要 目的：研究功能性核磁共振成像（fMRI）技术对原发性三叉神经痛（ITN）患者静息状态下脑功能的评估价值及血清白细胞介素-1β（IL-1β）、肿瘤坏死因子-α（TNF-α）检测的临床意义。方法：选取2017年2月～2019年2月安徽医科大学附属口腔医院接受诊治的ITN患者共50例进行研究，记为ITN组。另选取同期接受体检的健康人员50例记作健康对照组。两组均于静息状态下行fMRI扫描，比较两组脑区的平均低频振幅率（mfALFF）以及血清IL-1β、TNF-α水平。结果：ITN组左侧的枕中回、枕下回、梭状回、距状裂周围皮层、中央旁回、三角部额下回、右侧背外侧额上回以及左小脑脚1区的mfALFF值高于健康对照组（均P＜0.05）。ITN组右颞上回、右颞中回、右颞下回、右中央沟盖、右缘上回、右岛盖部颞下回、左前扣带回、扣带旁回、左颞极、颞上回脑区的mfALFF值显著低于健康对照组（均P＜0.05）。ITN组患者的血清IL-1β、TNF-α水平高于健康对照组（均P＜0.05）。结论：fMRI对ITN患者静息状态下脑功能的评估价值较高，血清IL-1β、TNF-α水平升高可能与ITN的发病密切相关，可发挥促进疾病发生、发展的作用。 |
| 英文摘要: |
| ABSTRACT Objective: To study the evaluation value of functional magnetic resonance imaging (fMRI) in brain function of patients with idiopathic trigeminal neuralgia (ITN) and the clinical significance of serum interleukin-1β(IL-1β) and tumor necrosis factor-α (TNF-α). Methods: A total of 50 patients with ITN who were treated in Stomatological Hospital Affiliated to Anhui Medical University from February 2017 to February 2019 were included in the study and recorded as ITN group. Another 50 healthy patients who received physical examination during the same period were recorded as healthy control group. Both groups were scanned by fMRI at rest. The levels of mean fractional amplitude of low frequency fluctuation (mfALFF), serum IL-1β and TNF-α in the two groups were compared. Results: The levels of mfALFF in the left middle occipital gyrus, inferior occipital gyrus, fusiform gyrus, calcinate fissure surrounding cortex, central paralateral gyrus, triangular inferior frontal gyrus, right dorsolateral superior frontal gyrus and left cerebellar region 1 in the ITN group were higher than those in the healthy control group (all P<0.05). In the ITN group, the mfALFF values of right superior temporal gyrus, right middle temporal gyrus, right inferior temporal gyrus, right central sulcus cover, right superior marginal gyrus, right inferior temporal gyrus, left anterior cingulate gyrus, paracingulate gyrus, left temporal polar and superior temporal gyrus were significantly lower than those in the healthy control group (all P<0.05). The levels of serum IL-1β and TNF-α in the ITN group were higher than those in the healthy control group (all P<0.05). Conclusion: The evaluation value of fMRI at brain function in resting state of patients with ITN is high. The elevated levels of serum IL-1β and TNF-α may be closely related to the pathogenesis of ITN, and it play a role in promoting the occurrence and development of the disease. |
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