| 贾晨红,哈生林,姜金坪,臧鸿斌,李 斌.慢性心力衰竭患者血清Galectin-3、hs-cTnT、Cys C和PTX-3水平变化及临床意义[J].,2020,(14):2672-2675 |
| 慢性心力衰竭患者血清Galectin-3、hs-cTnT、Cys C和PTX-3水平变化及临床意义 |
| Changes and Clinical Significance of Serum Galectin-3, hs-cTnT, Cys C and PTX-3 in Patients with Chronic Heart Failure |
| 投稿时间：2019-12-27 修订日期：2020-01-24 |
| DOI：10.13241/j.cnki.pmb.2020.14.015 |
| 中文关键词: 慢性心力衰竭 半乳糖凝聚素-3 正五聚体蛋白-3 高敏肌钙蛋白-T 胱抑素C |
| 英文关键词: Chronic heart failure Galactose agglutinin-3 Pentamer protein-3 High sensitivity troponin-T Cystatin C |
| 基金项目:辽宁省重点研发计划指导项目（2017225003） |
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| 中文摘要: |
| 摘要 目的：研究慢性心力衰竭（CHF）患者血清半乳糖凝聚素-3（Galectin-3）、高敏肌钙蛋白-T（hs-cTnT）、胱抑素C（Cys C）和正五聚体蛋白-3（PTX-3）水平变化及临床意义。方法：选择2017年2月～2018年6月我院收治的CHF患者100例，按照美国心脏病协会（NYHA）心功能分级标准将其分成NYHAⅡ级组39例、NYHAⅢ级组33例、NYHAⅣ级组28例，根据随访1年患者预后情况将主要心脏不良事件患者记作预后不良组（n=27），其余记为预后优良组（n=73），另取同期于我院进行体检的健康者30例作为对照组。分别比较CHF患者和对照组的心功能指标、血清Galectin-3、hs-cTnT、Cys C、PTX-3水平，分析CHF患者上述指标的相关性及其与CHF预后情况的关系。结果：对照组、NYHAⅡ级组、NYHAⅢ级组、NYHAⅣ级组左心室舒张末期内径（LVEDD）呈逐渐增大趋势，而左心室射血分数（LVEF）呈逐渐降低趋势（P<0.05）。对照组、NYHAⅡ级组、NYHAⅢ级组、NYHAⅣ级组血清Galectin-3、hs-cTnT、Cys C和PTX-3水平呈逐渐升高趋势（P<0.05）。经Pearson相关性分析可得：CHF患者LVEDD与血清Galectin-3、hs-cTnT、Cys C、PTX-3水平呈正相关关系，而LVEF与血清Galectin-3、hs-cTnT、Cys C、PTX-3水平呈负相关关系（P<0.05）。CHF预后优良组血清Galectin-3、hs-cTnT、Cys C、PTX-3水平均低于预后不良组（P<0.05）。结论：CHF血清Galectin-3、hs-cTnT、Cys C和PTX-3水平均呈明显高表达，且与患者的病情严重程度呈密切相关，临床上可通过检测上述指标水平，继而为CHF临床诊断、预后评估提供参考依据。 |
| 英文摘要: |
| ABSTRACT Objective: To study the changes and clinical significance of serum Galactose agglutinin-3 (Galectin-3), high sensitivity troponin-T (hs-cTnT), Cystatin C (Cys C), pentamer protein-3 (PTX-3) in patients with chronic heart failure (CHF). Methods: 100 CHF patients admitted to our hospital from February 2017 to June 2018 were selected, according to the New York Heart Association (NYHA) cardiac function classification standard, they were divided into NYHA II group 39 cases, NYHA III group 33 cases and NYHA IV group 28 cases. The patients with major adverse cardiac events were classified as poor prognosis group (n=27) and the others as good prognosis group (n=73) according to the prognosis of patients followed up for 1 year. Another 30 healthy patients who underwent physical examination in our hospital during the same period were selected as the control group. Cardiac function, serum Galectin-3, hs-cTnT, Cys C, PTX-3 levels were compared between CHF patients and control group, the correlation between the above indicators and the prognosis of CHF patients were analyzed. Results: The levels of left ventricular ejection fraction (LVEDD) in control group, NYHA II group, NYHA III group and NYHA IV group increased gradually, while the levels of end-diastolic diameter of left ventricle (LVEF) decreased gradually (P<0.05). The levels of Galectin-3, hs-cTnT, Cys C, PTX-3 in control group, NYHA II group, NYHA III group and NYHA IV group increased gradually(P<0.05). Pearson correlation analysis showed that LVEDD of CHF patients was positively correlated with serum Galectin-3, hs-cTnT, Cys C, PTX-3 levels, while LVEF was negatively correlated with serum Galectin-3, hs-cTnT, Cys C, PTX-3 levels (P<0.05). Serum Galectin-3, hs-cTnT, Cys C, PTX-3 levels in good prognosis group were lower than those in poor prognosis group (P<0.05). Conclusion: Serum Galectin-3, hs-cTnT, Cys C, PTX-3 levels of CHF are significantly high, which are closely related to the severity of the disease. The above indexes can be detected clinically to provide reference for the clinical diagnosis and prognosis evaluation of CHF. |
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