| 万晓强,郑紫丹,张霹雲,陈 佳,刘代江,彭 鹏.双歧杆菌三联活菌胶囊联合多烯磷脂酰胆碱对NAFLD患者肝功能、脂糖代谢及炎症因子的影响[J].,2020,(14):2719-2722 |
| 双歧杆菌三联活菌胶囊联合多烯磷脂酰胆碱对NAFLD患者肝功能、脂糖代谢及炎症因子的影响 |
| Effects of Bifidobacterium Triple Viable Capsule Combined with Polyene Phosphatidylcholine on Liver Function, Metabolism of Lipopolysaccharide and Inflammatory Factors in NAFLD Patients |
| 投稿时间：2019-12-28 修订日期：2020-01-24 |
| DOI：10.13241/j.cnki.pmb.2020.14.026 |
| 中文关键词: 多烯磷脂酰胆碱 双歧杆菌三联活菌胶囊 非酒精性脂肪性肝病 肝功能 脂糖代谢 炎症因子 |
| 英文关键词: Polyene phosphatidylcholine Bifidobacterium triple viable capsule Nonalcoholic fatty liver disease Liver function Lipopolysaccharide metabolism Inflammatory factors |
| 基金项目:重庆市卫计委基金项目（2015MSXM218） |
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| 摘要 目的：探讨双歧杆菌三联活菌胶囊联合多烯磷脂酰胆碱对非酒精性脂肪性肝病（NAFLD）患者肝功能、脂糖代谢及炎症因子的影响。方法：选取我院收治的123例NAFLD患者，根据乱数表法将患者分为对照组（n=61）和研究组（n=62），其中对照组给予多烯磷脂酰胆碱治疗，研究组在对照组的基础上联合双歧杆菌三联活菌胶囊治疗，比较两组临床疗效、肝功能、脂糖代谢及炎症因子，记录两组治疗期间不良反应情况。结果：研究组治疗12周后的临床总有效率为82.26%（51/62），高于对照组的63.93%（39/61）（P<0.05）。两组治疗12周后谷氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）、总胆红素（TBIL）、白介素-6（IL-6）、C反应蛋白（CRP）、肿瘤坏死因子-α（TNF-α）均下降，且研究组低于对照组（P<0.05）。研究组治疗12周后空腹血糖（FPG）、总胆固醇(TC)、低密度脂蛋白 (LDL-C)、甘油三酯(TG)均降低，且研究组低于对照组（P<0.05）。高密度脂蛋白 (HDL-C)升高，且研究组高于对照组（P<0.05）。两组不良反应发生率对比未见显著性差异（P>0.05）。结论：双歧杆菌三联活菌胶囊联合多烯磷脂酰胆碱治疗NAFLD，用药安全性较好，疗效确切，可有效改善患者肝功能、炎症因子水平及脂糖代谢。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of Bifidobacterium triple viable capsule combined with polyene phosphatidylcholine on liver function, lipid and glucose metabolism and inflammatory factors in patients with nonalcoholic fatty liver disease (NAFLD). Methods: 123 patients with NAFLD in our hospital were selected. The patients were randomly divided into control group (n=61) and study group (n=62) according to the method of random number table. The control group was treated with polyene phosphatidylcholine, and the study group was treated with Bifidobacterium triple viable Capsule on the basis of the control group. The clinical effect, liver function, lipid and sugar metabolism and inflammatory factors of the two groups were compared, and the adverse reactions during the treatment were recorded. Results: The total clinical effective rate of the study group was 82.26% (51/62), which was higher than 63.93% (39/61) of the control group (P<0.05). After 12 weeks of treatment, Glutamate aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL), interleukin-6 (IL-6), C-reactive protein (CRP), tumor necrosis factor -α (TNF -α) were all decreased in the two groups, which were lower in the study group than in the control group (P<0.05). The Total cholesterol (TC), high density lipoprotein (HDL-C), triglyceride (TG), ow density lipoprotein (LDL-C), fasting blood glucose (FPG) in the study group were all lower than those in the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion: Bifidobacterium triple viable capsule combined with polyene phosphatidylcholine can effectively improve the liver function, inflammatory factor level and glycolipid metabolism of patients with NAFLD. |
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