| 阿里旦·艾尔肯,阿里童·苏来曼,武 云,李鸣远,吴雷琪.气管哮喘患者血清趋化因子CXCL12水平的表达及其与炎症因子和肺功能的相关性研究[J].,2020,(15):2934-2938 |
| 气管哮喘患者血清趋化因子CXCL12水平的表达及其与炎症因子和肺功能的相关性研究 |
| Expression of CXCL12 in Serum of Patients with Asthma and Its Correlation with Inflammatory Factors and Pulmonary Function |
| 投稿时间：2020-04-06 修订日期：2020-04-30 |
| DOI：10.13241/j.cnki.pmb.2020.15.027 |
| 中文关键词: 支气管哮喘 趋化因子CXCL12 炎症因子 嗜酸性粒细胞 免疫球蛋白E 肺功能 |
| 英文关键词: Asthma CXCL12 Inflammatory factors EOS IgE Lung function |
| 基金项目:新疆维吾尔自治区自然科学基金项目（2017D01C331） |
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| 中文摘要: |
| 摘要 目的：探讨支气管哮喘患者血清趋化因子CXCL12水平与炎症因子和肺功能的关系。方法：选择2017年10月至2019年10月我院收治的支气管哮喘患者共106例，其中急性发作期67例（急性发作组）、慢性持续期39例（慢性持续组），另选择50例体检的健康志愿者为对照组，均进行血清CXCL12检测，分析CXCL12与炎症因子、肺功能、嗜酸性粒细胞（EOS）、免疫球蛋白E（IgE）、呼出气一氧化氮（FeNo）的相关性。结果：急性发作期组血清CXCL12、白介素-4（IL-4）、白介素-17A（IL-17A）、白介素-13（IL-13）、EOS、IgE、FeNO水平高于慢性持续期组和对照组（P＜0.05），慢性持续期组血清CXCL12、IL-4、IL-17A、IL-13、EOS、IgE、FeNO水平高于对照组（P＜0.05）；急性发作期组第1秒用力呼气容积（FEV1）、第1秒用力呼气容积与用力肺活量比值（FEV1/FVC）、第1秒用力呼气容积占预计值百分数(FEV1 %pred)低于慢性持续期组和对照组（P＜0.05），慢性持续期组FEV FEV1、FEV FEV1/FVC、FEV FEV1%pred低于对照组（P＜0.05）。多元线性回归分析结果显示血清CXCL12与支气管哮喘患者FEV FEV1、FEV FEV1/FVC呈负相关（P＜0.05），与EOS、IgE、IL-4、IL-17A、IL-13呈正相关（P＜0.05）。结论：CXCL12在支气管哮喘进程中可能发挥促炎作用，血清CXCL12水平可反映患者病情严重程度和肺通气功能。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between the level of CXCL12, inflammatory factors and pulmonary function in patients with asthma. Methods: From October 2017 to October 2019, 106 patients with bronchial asthma were selected in our hospital, including 67 patients in acute attack period (acute attack group), 39 patients in chronic duration period (chronic duration group), and 50 healthy volunteers for physical examination as the control group. Serum CXCL12 was detected, and the correlation between CXCL12 and inflammatory factors, lung function, eosinophil (EOS), Immunoglobulin E (IGE), Fractional Exhaled Nitric Oxide (FeNO) was analyzed. Results: The levels of CXCL12, Interleukin-4 (IL-4), Interleukin-17A(IL-17A), Interleukin-13 (IL-13), EOS, IgE and FeNO in the acute attack group were higher than those in the chronic persistent group and the control group (P < 0.05), and the levels of CXCL12, IL-4, IL-17A, IL-13, EOS, IgE and FeNO in the chronic persistent group were higher than those in the control group (P < 0.05). The forced expiratory volume in one second （FEV1）, ratio of forced expiratory volume in one second/ forced vital capacity (FEV1/ FVC) and the percentage of forced expiratory volume in one second % of estimated value (FEV1% pred) in the acute attack group were lower than those in the chronic attack group and the control group (P < 0.05). FEV1, FEV1 / FVC, FEV1% PRED in chronic duration group were lower than those in control group (P < 0.05). Multiple linear regression analysis showed that serum CXCL12 level was negatively correlated with FEV1 and FEV1 / FVC in asthmatic patients (P < 0.05), and positively correlated with EOS, IgE, IL-4, IL-17A and IL-13 (P < 0.05). Conclusion: CXCL12 may play an inflammatory role in the process of asthma. The serum level of CXCL12 can reflect the severity of the disease and pulmonary ventilation function. |
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