| 石紫云,李艳川,袁晓华,折开娥,李 虹.妊娠期高血压患者血清热休克蛋白70水平与心功能及免疫球蛋白的关系研究[J].,2020,(17):3252-3255 |
| 妊娠期高血压患者血清热休克蛋白70水平与心功能及免疫球蛋白的关系研究 |
| Study on the Relationship between Serum Heat Shock Protein 70 Level and Heart Function and Immunoglobulin in Hypertensive Patients during Pregnancy |
| 投稿时间：2020-01-30 修订日期：2020-02-24 |
| DOI：10.13241/j.cnki.pmb.2020.17.011 |
| 中文关键词: 妊娠期高血压 热休克蛋白70 心功能 超声心动图 免疫球蛋白 |
| 英文关键词: Gestational hypertension Heat shock protein 70 Cardiac function Echocardiographic structure Ultrasonic function Immunoglobulin |
| 基金项目:国家自然科学基金青年基金项目（81200418） |
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| 中文摘要: |
| 摘要 目的：探究妊娠期高血压患者血清热休克蛋白70（HSP70）水平与心功能及免疫球蛋白的关系。方法：选择2017年4月至2018年4月在陕西省人民医院诊治的200例妊娠期高血压患者作为妊娠期高血压组，同时选择同期在我院进行孕检的200名健康孕妇作为对照组。采用酶联免疫吸附法检测血清HSP70水平，采用全自动生化分析仪检测免疫球蛋白G（IgG）、免疫球蛋白M（IgM）、免疫球蛋白A（IgA）、免疫球蛋白D（IgD）和免疫球蛋白E（IgE）水平，采用多普勒超声心动图监测两组的左心室后壁厚度（LVPWT）、左心室舒张末期内径（LVEDD）和室间隔厚度（IVST）、左心室收缩末期内径（LVESD）、左心室射血分数（LVEF）和每搏指数（SVI），计算左心室质量（LVM）、二尖瓣舒张早期血流速度峰值与二尖瓣环侧壁舒张早期运动峰速度的比值（E/Em）、舒张早期与舒张晚期血流速度峰值的比值（E/A）。采用spearman相关性分析血清HSP70水平与血清免疫球蛋白水平及心功能指标的相关性。结果：与对照组相比，妊娠期高血压组的血清HSP70水平明显升高，而IgG和IgM水平明显下降，并且LVESD、LVEF、E/A也明显下降（P<0.05）。血清HSP70水平与IgG、IgM、LVESD、LVEF、E/A均呈负相关性（P<0.05）。结论：妊娠期高血压患者的血清HSP70水平明显升高，并且血清HSP70水平与妊娠期高血压患者免疫功能和心功能下降存在相关性，在妊娠期高血压患者的诊断和治疗中具有一定临床价值。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between serum heat shock protein 70 (HSP70) level and cardiac function and immunoglobulin in hypertensive patients during pregnancy. Methods: 200 patients with gestational hypertension diagnosed and treated in shaanxi provincial people's hospital from April 2017 to April 2018 were selected as the gestational hypertension group, and 200 normal pregnant women who underwent pregnancy examination in our hospital during the same period were selected as the normal pregnancy group. Serum HSP70 level was detected by ELISA. Immunoglobulin G (IgG), immunoglobulin M (IgM), immunoglobulin A (IgA), immunoglobulin D (IgD) and immunoglobulin E (IgE) levels were measured by automatic biochemical analyzer. The left ventricular posterior wall thickness (LVPWT), left ventricular end diastolic diameter (LVEDD), interventricular septal thickness (IVST), left ventricular end systolic diameter (LVESD), left ventricular ejection fraction (LVEF) and stroke index (SVI) were measured by Doppler echocardiography. The left ventricular mass (LVM), the peak value of early diastolic velocity and the diastolic value of the annular wall of the mitral valve were calculated The ratio of peak velocity of early exercise (E/Em), the ratio of peak velocity of early diastolic to late diastolic (E/A). Spearman correlation analysis was used to test the correlation between serum HSP70 level and IgG and IgM levels as well as LVESD and LVEF. Results: Compared with the control group, the level of serum HSP70 was significantly higher, the level of IgG and IgM was significantly lower, and the levels of LVESD, LVEF, E/A were also significantly lower (P<0.05). The level of serum HSP70 was negatively correlated with IgG, IgM, LVESD, LVEF and E/A (P<0.05). Conclusion: Serum HSP70 level in patients with gestational hypertension was significantly increased, and serum HSP70 level was correlated with decreased immune function and cardiac function in patients with gestational hypertension, which had certain clinical value in the diagnosis and treatment of patients with gestational hypertension. |
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