| 王意君,曹 颖,徐晓辉,喻 国,徐 畅,邓洪波.2型糖尿病患者血清三叶因子3、磷酸酪氨酸衔接蛋白1水平与肾功能及炎症反应的关系研究[J].,2020,(17):3329-3332 |
| 2型糖尿病患者血清三叶因子3、磷酸酪氨酸衔接蛋白1水平与肾功能及炎症反应的关系研究 |
| Relationship between Serum Trefoil Factor 3, Phosphoric Tyrosine Binding Protein 1 and Renal Function and Inflammatory Response in Patients with Type 2 Diabetes Mellitus |
| 投稿时间：2019-11-29 修订日期：2019-12-24 |
| DOI：10.13241/j.cnki.pmb.2020.17.029 |
| 中文关键词: 2型糖尿病 三叶因子3 磷酸酪氨酸衔接蛋白1 肾功能 炎症反应 |
| 英文关键词: Type 2 diabetes mellitus Trefoil factor 3 Phosphoric tyrosine binding protein 1 Renal function Inflammatory response |
| 基金项目:四川省科研基金项目（18ZD006） |
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| 中文摘要: |
| 摘要 目的：探讨2型糖尿病（T2DM）患者血清三叶因子3（TFF3）、磷酸酪氨酸衔接蛋白1（APPL1）水平，并分析其与肾功能及炎症反应之间的关系。方法：选择2017年1月至2019年1月期间我院收治的T2DM患者168例，根据尿白蛋白/肌酐比率（UACR）将患者分为正常白蛋白尿组（UACR<30 mg/g，n=79）、微量白蛋白尿组（30 mg/g≤UACR≤300 mg/g，n=65）和大量白蛋白尿组（UACR＞300 mg/g，n=24），另选择同期行体检的健康志愿者57例作为对照组。对比四组受试者血清TFF3、APPL1水平、肾功能指标[血尿素（UREA）、血肌酐（Scr）、胱抑素C（Cys C）和肾小球滤过率（GFR）]及炎症指标[肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）、白细胞介素-10（IL-10）及单核细胞趋化因子1（MCP-1）]变化，Pearson相关分析血清TFF3、APPL1水平与肾功能指标及炎症因子的相关性。结果：四组受试者血清TFF3、APPL1、肾功能指标、TNF-α、IL-6及MCP-1之间的差异具有统计学意义（P<0.05）；与对照组相比，T2DM患者血清TFF3、APPL1、UREA、Scr、Cys C、TNF-α、IL-6及MCP-1水平均明显升高，而GFR显著下降，且差异均具有统计学意义（PP0.05）；不同UACR水平的T2DM患者血清TFF3、APPL1、肾功能指标、TNF-α、IL-6及MCP-1之间的差异具有统计学意义（P<0.05）；Pearson相关分析结果显示，T2DM患者血清TFF3、APPL1分别与UREA、Scr、Cys C、TNF-α、IL-6、MCP-1呈正相关（P<0.05），与GFR呈负相关（P<0.05），但是与IL-10无相关性（P>0.05）。结论：血清TFF3和APPL1可能通过影响肾功能及炎症反应而影响T2DM的发生及发展，可能作为T2DM临床诊断的生物学指标，为T2DM的治疗提供新靶点。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the serum levels of trefoil factor 3 (TFF3) and phosphoric tyrosine binding protein 1(APPL1) in patients with type 2 diabetes mellitus (T2DM), and to analyze and to analyze their relationship with renal function and inflammatory response. Methods: 168 patients with T2DM in our hospital from January 2017 to January 2019 were selected, the patients were divided into normal albuminuria group (UACR<30 mg/g, n=79), micro albuminuria group (30 mg/g≤UACR≤300 mg/g, n=65) and large albuminuria groups (UACR＞300 mg/g, n=24) according to the urinary albumin/creatinine ratio (UACR), another 57 healthy volunteers during the same period were selected as control group. The serum TFF3, APPL1 levels, the changes of renal function index [blood urea (UREA), serum creatinine (Scr), cystatin C (Cys C) and glomerular filtration rate (GFR)], the changes of inflammatory markers [tumor necrosis factor-α (TNF-α), interleukin -6 (IL-6), interleukin -10 (IL-10) and monocyte chemoattractant 1 (MCP-1)] in four groups of subjects were compared, the correlation between serum TFF3, APPL1 levels, renal function and inflammatory factors were analyzed by pearson correlation analysis. Results: The differences in serum TFF3, APPL1, renal function, TNF-α, IL-6 and MCP-1 between the four groups were statistically significant (P<0.05). Compared with the control group, the levels of TFF3, APPL1, UREA, Scr, Cys C, TNF-α, IL-6 and MCP-1 in the serum of T2DM patients were significantly increased, while GFR was significantly decreased, and the differences were statistically significant (P<0.05). The differences of serum TFF3, APPL1, renal function, TNF-α, IL-6 and MCP-1 between T2DM patients with different UACR levels were statistically significant(P<0.05). Pearson correlation analysis showed that serum TFF3 and APPL1 in T2DM patients were positively correlated with UREA, Scr, Cys C, TNF-α, IL-6 and MCP-1(P<0.05), which was negatively correlated with GFR(P<0.05), but there was no correlation with IL-10 (P>0.05). Conclusion: Serum TFF3 and APPL1 can affect the occurrence and development of T2DM by affecting renal function and inflammatory response, which may be important biological indexes for the clinical diagnosis of T2DM and provide a new target for the treatment of T2DM. |
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