| 王 莉,冯仕品,罗 苇,谢 敏,刘 君.玉屏风颗粒联合他克莫司对原发性肾病综合征患儿肾功能、免疫功能以及Th1/Th2细胞平衡的影响[J].,2020,(17):3354-3357 |
| 玉屏风颗粒联合他克莫司对原发性肾病综合征患儿肾功能、免疫功能以及Th1/Th2细胞平衡的影响 |
| Effect of Yupingfeng Granule Combined with Tacrolimus on Renal Function, Immune Function and Th1/Th2 Cell balance in Children with Primary Nephrotic Syndrome |
| 投稿时间：2020-03-23 修订日期：2020-04-18 |
| DOI：10.13241/j.cnki.pmb.2020.17.035 |
| 中文关键词: 玉屏风颗粒 他克莫司 原发性肾病综合征 肾功能 免疫功能 Th1/Th2细胞 |
| 英文关键词: Yupingfeng granule Tacrolimus Primary nephrotic syndrome Renal function Immune function Th1/Th2 cell |
| 基金项目:四川省卫生健康委员会科研基金项目（19PJ020） |
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| 中文摘要: |
| 摘要 目的：探讨玉屏风颗粒联合他克莫司对原发性肾病综合征（PNS）患儿肾功能、免疫功能以及Th1/Th2细胞平衡的影响。方法：选取2017年1月~2019年6月期间我院收治的PNS患儿97例，根据随机数字表法将患者分为对照组（n=48）和研究组（n=49），对照组患儿给予他克莫司治疗，研究组在对照组的基础上联合玉屏风颗粒治疗，比较两组患儿疗效、肾功能指标[尿素氮（BUN）、血肌酐（Scr）、免疫功能指标[CD3+、CD4+/CD8+、免疫球蛋白G（IgG）、免疫球蛋白A（IgA）]以及Th1/Th2细胞平衡因子[Th1细胞分泌的白细胞介素-2（IL-2）、转化生长因子-β1（TGF-β1）及Th2细胞分泌的白介素-6（IL-6）、白介素-10（IL-10）]，记录两组治疗期间不良反应发生情况。结果：研究组治疗9个月后的临床总有效率为91.84%（45/49），高于对照组的75.00%（36/48）（P<0.05）。两组治疗9个月后Scr、BUN均下降，且研究组低于对照组（P<0.05）。两组治疗9个月后CD3+、CD4+/CD8+、IgG、IgA均升高，且研究组高于对照组（P<0.05）。两组不良反应发生率比较无差异（P>0.05）。两组治疗9个月后TGF-β1、IL-2、IL-10、IL-6均下降，且研究组低于对照组（P<0.05）。结论：玉屏风颗粒联合他克莫司治疗PNS患儿，疗效显著，可有效改善患儿肾功能、免疫功能以及Th1/Th2细胞平衡，且不增加不良反应发生率，安全可靠。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of Yupingfeng granule combined with tacrolimus on renal function, immune function and Th1/Th2 cell balance in children with primary nephrotic syndrome (PNS). Methods: 97 children with PNS who were admitted to our hospital from January 2017 to June 2019 were selected, they were randomly divided into two groups: control group (n=48) and study group (n=49). The control group was treated with tacrolimus, and the study group was treated with Yupingfeng Granule on the basis of the control group. The curative effect and renal function indexes [urea nitrogen (BUN), blood creatinine (Scr)] , immune function indexes [CD3+, CD4+/CD8+, immunoglobulin G (IgG), immunoglobulin A (IGA)] and Th1/Th2 cell balance factor [interleukin-2 (IL-2), transforming growth factor -β1 (TGF -β1), interleukin-6 (IL-6), interleukin-10 (IL-10)] of the two groups were compared, and adverse reactions during treatment were recorded. Results: The total clinical effective rate of the study group was 91.84% (45/49), which was higher than 75.00% (36/48) of the control group (P<0.05). 9 months after treatment, Scr and BUN decreased in the two groups, and the study group was lower than the control group (P<0.05). 9 months after treatment, CD3+, CD4+/ CD8+, IgG and IgA in the two groups were all increased, and those in the study group were higher than those in the control group (P<0.05). There was no difference in the incidence of adverse reactions between the two groups (P>0.05). 9 months after treatment, TGF -β1, IL-2, IL-10 and IL-6 decreased in both groups, and the study group was lower than the control group. Conclusion: Yupingfeng granule combined with tacrolimus can improve the renal function, immune function and Th1/Th2 cell balance of children with PNS. It is safe and reliable. |
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