| 陈红霞,方春丽,王 辉,胡菲菲,应小燕.宫腔镜电切术联合左炔孕酮宫内节育系统对子宫内膜息肉患者性激素、炎症因子及复发的影响[J].,2020,(19):3691-3694 |
| 宫腔镜电切术联合左炔孕酮宫内节育系统对子宫内膜息肉患者性激素、炎症因子及复发的影响 |
| Effect of Hysteroscopic Resection Combined with Levonorgestrel Intrauterine Contraceptive System on Sex Hormones, Inflammatory Factors and Recurrence in Patients with Endometrial Polyps |
| 投稿时间：2020-04-06 修订日期：2020-04-28 |
| DOI：10.13241/j.cnki.pmb.2020.19.018 |
| 中文关键词: 宫腔镜电切术 左炔孕酮宫内节育系统 子宫内膜息肉 性激素 炎症因子 复发 |
| 英文关键词: Hysteroscopic resection Levonorgestrel intrauterine contraceptive system Endometrial polyps Sex hormones Inflammatory factors Recurrence |
| 基金项目:江苏省自然科学基金面上项目（BK20171512） |
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| 中文摘要: |
| 摘要 目的：探讨宫腔镜电切术联合左炔孕酮宫内节育系统（LNG-IUS）对子宫内膜息肉患者炎症因子、性激素及复发的影响。方法：选取2016年4月到2018年4月期间我院收治的98例子宫内膜息肉患者，分为对照组与联合组，各49例。对照组予以宫腔镜电切术治疗，联合组予以宫腔镜电切术联合LNG-IUS治疗，比较两组性激素、炎症因子及复发情况，记录两组不良反应发生情况，观察两组月经周期、月经量、子宫内膜厚度。结果：术后6个月，两组月经周期、月经量、子宫内膜厚度均较术前降低，且联合组低于对照组（P<0.05）。两组术前、术后6个月卵泡生成激素（FSH）、黄体生成激素（LH）、雌二醇（E2）比较无显著性差异（P>0.05）。术后6个月，两组白介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、C反应蛋白（CRP）均较术前降低，且联合组低于对照组（P<0.05），白介素-4（IL-4）升高，且联合组高于对照组（P<0.05）。两组不良反应发生率对比未见显著性差异（P>0.05）。联合组复发率低于对照组（P<0.05）。结论：宫腔镜电切术联合LNG-IUS治疗子宫内膜息肉患者，可有效阻止息肉生长，降低复发率，对性激素水平影响较小，其作用机制可能与抑制炎症反应有关。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of hysteroscopic resection combined with levonorgestrel intrauterine contraceptive system (LNG-IUS) on sex hormones, inflammatory factors and recurrence in patients with endometrial polyps. Methods: 98 patients with endometrial polyps in our hospital from April 2016 to April 2018 were selected, and randomly divided into control group and combined group, 49 cases in each group. The control group was treated with hysteroscopic resection, and the combined group was treated with hysteroscopic resection combined with LNG-IUS. The sex hormones, inflammatory factors and recurrence of the two groups were compared, and the incidence of adverse reactions in the two groups was recorded. The menstrual cycle, menstrual volume and endometrial thickness of the two groups were observed. Results: 6 months after operation, the menstrual period, menstrual volume and endometrial thickness of the two groups were lower than those before operation, and those of the combined group were lower than those of the control group (P<0.05). There were no significant differences in follicle-generating hormone(FSH), luteinizing hormone(LH), estradiol(E2) between the two groups before and 6 months after operation(P>0.05). 6 months after operation, the interleukin-6(IL-6), tumor necrosis factor-α (TNF-α), C-reactive protein(CRP) in the two groups were lower than those before operation, and those of the combined group were lower than those of the control group(P<0.05), and the interleukin-4 (IL-4) increased, and that of the combined group was higher than that of the control group(P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). The recurrence rate of the combined group was lower than that of the control group(P<0.05). Conclusion: Hysteroscopic resection combined with LNG-IUS in the treatment of endometrial polyps can effectively prevent the growth of endometrial polyps, reduce the recurrence rate, and have little effect on the levels of sex hormones. The mechanism may be related to the inhibition of inflammatory reaction. |
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