| 相 莲,高 琳,王 蓓,颜 晖,马 莹.不同放散试验对新生儿ABO溶血病的诊断价值对比[J].,2020,(19):3792-3796 |
| 不同放散试验对新生儿ABO溶血病的诊断价值对比 |
| Comparison of the Diagnostic Values of Different Release Tests for the Neonatal ABO Hemolytic Disease |
| 投稿时间：2020-01-30 修订日期：2020-02-26 |
| DOI：10.13241/j.cnki.pmb.2020.19.042 |
| 中文关键词: 冷冻复融放散试验 改良热放散试验 新生儿ABO溶血病 敏感性 特异性 |
| 英文关键词: Freezing thawing test Improved thermal elution test ABO hemolytic disease of newborn Sensitivity Specific |
| 基金项目:国家自然科学基金青年基金项目（81602902） |
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| 中文摘要: |
| 摘要 目的：分析与比较不同放散试验对新生儿ABO溶血病的诊断价值。方法：选择2017年9月至2019年6月在本院进行ABO溶血病检测的新生儿240例，取所有新生儿的静脉血样本2~3 mL，采用冷冻复融放散试验方法与改良热放散试验方法检测新生儿ABO溶血病的发生情况，并比较单独诊断和联合诊断的价值。结果：在240份标本中，冷冻复融放散试验检出新生儿ABO溶血病阳性130例，阳性检出率为54.2 %；改良热放散试验检出新生儿ABO溶血病阳性94例，阳性检出率为39.2 %；二者联合检出新生儿ABO溶血病阳性100例，阳性检出率为41.67 %，联合检出新生儿ABO溶血病阳性率和冷冻复融放散试验检出新生儿ABO溶血病阳性率显著高于改良热放散试验检出新生儿ABO溶血病阳性率(P<0.05)。临床最终诊断为新生儿ABO溶血病101例，阳性率为42.08 %，患儿ABO血型包括A型56例，B型45例。冷冻复融放散试验诊断新生儿ABO溶血病的敏感性和特异性为73.8 %和95.5 % ，ROC曲线面积0.775；改良热放散试验检诊断为新生儿ABO溶血病的敏感性和特异性为100 %和95.2 %，ROC曲线面积0.853；二者联合诊断对新生儿ABO溶血病的敏感性和特异性为90.0 %和97.85 %，ROC曲线面积0.872，联合诊断特异性优于改良热放散试验检诊和冷冻复融放散试验诊断，且改良热放散试验检诊敏感性优于冷冻复融放散试验诊断。结论：相对于冷冻复融放散试验，改良热放散试验对新生儿ABO溶血病的诊断敏感性更高，且不影响诊断特异性，两种放散方法联合检测具有更好的应用价值。 |
| 英文摘要: |
| ABSTRACT Objective: To explore and compare the diagnostic values of different radiation tests for neonatal ABO hemolytic disease. Methods: From September 2017 to June 2019, 240 cases of neonates were selected for ABO hemolytic disease testing in our hospital, and 2~3 mL of venous blood samples from all newborns were collected. The freezing thawing test method and the improved thermal elution test methods were to detect the occurrence of ABO hemolytic disease in newborns and compare the value of individual diagnosis and combined diagnosis. Results: There were 130 cases of neonatal ABO hemolytic disease were detected by the freezing thawing test in the 240 cases, and the positive detection rate was 54.2 %. In the improved thermal elution test, 94 cases of neonatal ABO hemolytic disease were positive, and the positive detection rate was 39.2 %. The combined detection of 100 cases of neonatal ABO hemolytic disease was positive, with a positive detection rate of 41.67 %. The positive rate of neonatal ABO hemolytic disease combined with the freezing thawing test was significantly higher than that of the improved thermal elution test for neonatal ABO hemolytic disease (P<0.05). The final clinical diagnosis were 101 cases of neonatal ABO hemolytic disease, with a positive rate of 42.08 %. The ABO blood type of children included 56 cases of type A, 45 cases of type B. The sensitivity and specificity of the freezing thawing test to diagnose neonatal ABO hemolytic disease were 73.8 % and 95.5 %, and the ROC curve area was 0.775. The sensitivity and specificity of the improved thermal elution test to diagnose neonatal ABO hemolytic disease were 100 % and 95.2 %, and the ROC curve area was 0.853. The sensitivity and specificity of the combined diagnosis of the two for neonatal ABO hemolytic disease are 90.0 % and 97.85 %, and the ROC curve area is 0.872. The specificity of the combined diagnosis is superior to the improved thermal elution test diagnosis and freezing thawing test diagnosis. The diagnostic sensitivity of the improved thermal elution test is better than that of freezing thawing test. Conclusion: Compares with the freezing thawing test, the improved thermal elution test was more sensitive to the diagnosis of ABO hemolytic disease in newborns without affecting the diagnostic specificity. The combined detection of the two release methods have better application value. |
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