| 闫永宏,武淑华,来治国,卢青军,勾利静.负压封闭引流技术联合游离植皮治疗深度烧伤创面的疗效及对患者血清炎性因子及疼痛介质的影响[J].,2020,(20):3875-3878 |
| 负压封闭引流技术联合游离植皮治疗深度烧伤创面的疗效及对患者血清炎性因子及疼痛介质的影响 |
| The Curative Effect of Vacuum Sealing Drainage Technology Combined with Free Skin Grafting in the Treatment of Deep Burn Wounds and Its Influence on Serum Inflammatory Factors and Pain Mediators |
| 投稿时间：2020-06-04 修订日期：2020-06-27 |
| DOI：10.13241/j.cnki.pmb.2020.20.016 |
| 中文关键词: 负压封闭引流技术 游离植皮 深度烧伤创面 疗效 炎性因子 疼痛介质 |
| 英文关键词: Vacuum sealing drainage technology Free skin grafting Deep burn wounds Curative effect Inflammatory factors Pain mediators |
| 基金项目:河北省自然科学基金项目（H2015105083） |
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| 中文摘要: |
| 摘要 目的：探讨负压封闭引流技术（VSD）联合游离植皮治疗深度烧伤创面的疗效及对患者血清炎性因子及疼痛介质的影响。方法：选取2018年2月~2020年2月期间我院收治的103例深度烧伤患者，按乱数表法分为研究组51例及对照组52例，对照组患者给予游离植皮治疗，研究组在对照组基础上联合VSD，比较两组平均换药次数、平均住院时间、创面愈合时间、细菌培养阳性率、首次植皮存活率、创面愈合率、并发症、炎性因子[白介素-6（IL-6）、C反应蛋白（CRP）、肿瘤坏死因子-α（TNF-α）]以及疼痛介质[5-羟色胺（5-HT）、脑内神经肽（NPY）、前列腺素E2（PGE2）]水平。结果：研究组平均换药次数少于对照组，创面愈合时间、平均住院时间短于对照组（P<0.05）。研究组细菌培养阳性率低于对照组（P<0.05），研究组首次植皮存活率、创面愈合率均高于对照组（P<0.05）。治疗后，两组IL-6、CRP、TNF-α、5-HT、NPY、PGE2水平均较治疗前下降，且研究组低于对照组（P<0.05）。研究组的并发症发生率为5.88%（3/51），低于对照组的21.15%（11/52）（P<0.05）。结论：深度烧伤创面采用游离植皮联合VSD技术修复疗效显著，可有效促进创面愈合，降低并发症发生风险，降低炎性因子及疼痛介质水平。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the curative effect of vacuum sealing drainage (VSD) technology combined with free skin grafting in the treatment of deep burn wounds and its influence on serum inflammatory factors and pain mediators. Methods: 103 cases of deep burn patients in our hospital from February 2018 to February 2020 were selected, and divided into study group with 51 cases and control group with 52 cases according to random number table method. Patients in control group were treated with free skin grafting, and study group were combined with VSD on the basis of control group. The average dressing change times, average hospitalization time, wound healing time, bacterial culture positive rate, first skin graft survival rate, wound healing rate, complications, inflammatory factors [interleukin-6 (IL-6), C-reactive protein (CRP), tumor necrosis factor-α (TNF-α)] and pain mediators[5-hydroxytryptamine (5-HT), brain neuropeptide (NPY), prostaglandin E2 (PGE2)] levels were compared between the two groups. Results: The average dressing change times of the study group was less than that of the control group, and the average hospitalization time and wound healing time of the study group were shorter than those of the control group (P<0.05). The bacterial culture positive rate of the study group was lower than that of the control group (P<0.05), the first skin graft survival rate and wound healing rate of study group were higher than those of control group (P<0.05). After treatment, the levels of IL-6, CRP, TNF-α, 5-HT, NPY and PGE2 of the two groups were lower than those before treatment, and the study group was lower than the control group(P<0.05). The incidence of complications in the study group was 5.88% (3/51) lower than that in the control group 21.15%(11/52)(P<0.05). Conclusion: The application of free skin grafting combined with VSD technology in deep burn wounds repair has a significant curative effect, which can effectively promote wound healing, reduce the risk of complications, and reduce the level of inflammatory factors and pain mediators. |
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