| 左 帆,张旭祥,吴 斌,蒋世钊,念 馨,关雅心,赵 娟.妊娠期糖尿病患者血清NRG4、FGF-23、PGRN水平及其临床意义[J].,2020,(20):3961-3964 |
| 妊娠期糖尿病患者血清NRG4、FGF-23、PGRN水平及其临床意义 |
| Expression and Clinical Significance of Serum NRG4, FGF-23 and PGRN Levels in Patients with Gestational Diabetes Mellitus |
| 投稿时间：2020-04-23 修订日期：2020-05-18 |
| DOI：10.13241/j.cnki.pmb.2020.20.035 |
| 中文关键词: 妊娠期糖尿病 神经调节蛋白4 成纤维细胞生长因子-23 前颗粒体蛋白 糖脂代谢 胰岛素抵抗 |
| 英文关键词: Gestational diabetes Neuregulin 4 Fibroblast growth factor-23 Progranulin Glucose and lipid metabolism Insulin resistance |
| 基金项目:云南省卫生科技计划项目（2017NS050） |
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| 中文摘要: |
| 摘要 目的：探讨妊娠期糖尿病患者血清神经调节蛋白4(NRG4)、成纤维细胞生长因子-23(FGF-23)、前颗粒体蛋白(PGRN)水平及其临床意义。方法：选择2018年4月至2019年11月我院诊治的90例妊娠期糖尿病患者作为糖尿病组，选择同期在我院进行健康体检的90名健康孕妇作为对照组。检测两组血清NRG4、FGF-23、PGRN水平，血脂指标[高密度脂蛋白（HDL）、总胆固醇（TC）、甘油三酯（TG）和低密度脂蛋白（LDL）]水平，肝功能指标[谷草转氨酶（AST）、谷丙转氨酶(ALT)]水平，血糖和胰岛素指标[空腹血糖（FPG）、空腹胰岛素(FINS)]水平，并计算抗胰岛素抵抗指数(HOMA-IR)、胰岛素敏感性指数（ISI）和胰岛?茁细胞功能指数(HOMA-β)。分析各临床指标间的关系。结果：与对照组相比，糖尿病组体质量指数（BMI）、TG、TC、FPG、FINS、HOMA-IR、NRG4、FGF-23、PGRN明显升高（P<0.05），ISI和HOMA-β明显下降（P<0.05）。血清NRG4、FGF-23、PGRN与ISI和HOMA-β均呈负相关（P<0.05），与BMI、TG、TC、FPG、FINS、HOMA-IR均呈正相关（P<0.05）。TG与NRG4表达联系密切（β=0.007，P<0.05），ISI和HOMA-IR与FGF-23表达联系密切（β=-6.674、0.048，P<0.05），FPG和TC与PGRN表达联系密切（β=22.308、0.507，P<0.05）。结论：妊娠期糖尿病患者血清NRG4、FGF-23、PGRN水平异常升高，并参与妊娠期糖尿病患者的糖脂代谢和胰岛素抵抗，检测其水平有助于评估妊娠期糖尿病的糖脂代谢异常情况。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the expression and clinical significance of serum neuregulin 4 (NRG4), fibroblast growth factor-23 (FGF-23) and progranulin (PGRN) levels in patients with gestational diabetes mellitus. Methods: 90 patients with gestational diabetes who were diagnosed and treated in our hospital from April 2018 to November 2019 were selected as the diabetes group, and 90 healthy pregnant women who underwent physical examination in our hospital during the same period were selected as the control group. Serum NRG4, FGF-23, PGRN levels, blood lipid index [high-density lipoprotein (HDL), triglyceride (TG), total cholesterol (TC) and low density lipoprotein (LDL)] levels, liver function index [aspertate aminotransferase (AST), alanine aminotransferase (ALT)] level, blood sugar and insulin index [fasting plasma glucose (FPG), fasting insulin (FINS)] levels of two groups were detected, the insulin resistance index (HOMA-IR), insulin sensitivity index (ISI) and islet insulin function index (HOMA-β) were also calculated. The relationship between clinical indexes were analyzed. Results: Compared with the control group, body mass index (BMI), TG, TC, FPG, FINS, HOMA-IR, NRG4, FGF-23 and PGRN levels in the diabetes group were significantly increased (P<0.05), and ISI and HOMA-β were significantly decreased (P<0.05). Serum NRG4, FGF-23, PGRN were negatively correlated with ISI and HOMA-β (P<0.05), and were positively correlated with BMI, TG, TC, FPG, FINS and HOMA-IR (P<0.05). TG was closely correlated with NRG4 expression (β=0.007, P<0.05), ISI and HOMA-IR were closely correlated with FGF-23 expression (β=-6.674, 0.048; P<0.05), and FPG and TC were closely correlated with PGRN expression (β=22.308, 0.507; P<0.05). Conclusion: Serum NRG4, FGF-23 and PGRN levels in patients with gestational diabetes mellitus are abnormally elevated, and they are involved in glucose and lipid metabolism and insulin resistance in patients with gestational diabetes mellitus, the detection of them is helpful to evaluate the abnormal glucose and lipid metabolism in gestational diabetes mellitus. |
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