| 高淑靖,潘静琳,刘凤斌,庄昆海,赵利娜.温中消疡汤对非甾体抗炎药相关性胃溃疡的疗效研究[J].,2020,(21):4076-4079 |
| 温中消疡汤对非甾体抗炎药相关性胃溃疡的疗效研究 |
| Study on Therapeutic Effect of Wenzhong Xiaoyang Decoction on Non-steroidal Anti-inflammatory Drugs Related Gastric Ulcer |
| 投稿时间：2020-05-02 修订日期：2020-05-26 |
| DOI：10.13241/j.cnki.pmb.2020.21.016 |
| 中文关键词: 温中消疡汤 NSAIDs相关性胃溃疡 疗效 |
| 英文关键词: Wenzhong Xiaoyang Decoction NSAIDs-related gastric ulcer Curative effect |
| 基金项目:国家自然科学基金青年基金项目（81904145） |
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| 中文摘要: |
| 摘要 目的：考察温中消疡汤对非甾体类抗炎药(Non-steroidal anti-inflammatory drugs，NSAIDs)相关性胃溃疡的临床疗效。方法：以80例2017年2月-2020年1月就诊于我院NSAIDs相关性胃溃疡患者为研究对象，采用随机数字表法分为研究组和对照组，每组40例。对照组患者进行口服雷贝拉唑治疗，研究组在对照组的基础上服用温中消疡汤。对中医证候疗效指标、中医证候积分和胃镜下疗效对治疗效果进行评价。结果：对两组患者中医证候疗效进行比较，研究组的总有效率为90.00 %，显著高于对照组的77.50 %(P＜0.05)。对治疗前后两组患者的中医证候（胃脘疼痛、腹胀、纳呆食少、反酸、嗳气、倦怠乏力、大便稀溏）积分进行比较，显示治疗前两组各证候积分及总积分无明显差异（P＞0.05）；经过治疗，两组患者各项证候积分及总积分均显著降低(P＜0.05)；与对照组相比，研究组胃脘疼痛、腹胀、纳呆食少、反酸及总积分均显著减低(P＜0.05)。对两组患者胃镜下黏膜改善情况进行比较，研究组的总有效率为97.50 %，显著高于对照组的87.50 %(P＜0.05)。结论：温中消疡汤治疗NSAIDs相关性胃溃疡，能显著提高对NSAIDs相关性胃溃疡的疗效，能更好的改善胃脘疼痛、腹胀、纳呆食少等症状，能明显促进胃黏膜的恢复。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the clinical effect of Wenzhong Xiaoyang Decoction on non-steroidal anti-inflammatory drug-related gastric ulcer. Methods: A total of 80 patients with NSAIDs-related gastric ulcer who were admitted to our hospital from February 2017 to January 2020 were selected as the research object. They were divided into a study group and a control group by random number table method, with 40 cases in each group. The patients in the control group were treated with rabeprazole by mouth, and the study group took Wenzhong Xiaoyang Decoction based on the control group. The curative effect index of TCM syndromes, the score of TCM syndromes and the efficacy under gastroscope were evaluated. Results: Comparing the efficacy of TCM syndromes of the two groups of patients, the total effective rate of the study group was 90.00 %, which was significantly higher than that of the control group (77.50 %). Compare the points of TCM syndromes (stomach pain, abdominal distension, lack of appetite, less acid, acid reflux, belching, fatigue, fatigue, loose stools) of the two groups of patients before and after treatment, there was no significant difference in the points and total points of the two groups before treatment (P>0.05). After treatment, the syndrome points and total points of the two groups of patients were significantly reduced (P<0.05). Compared with the control group, the stomach pain, abdominal distension, less appetite, acid reflux and total points of the study group were significantly reduced (P<0.05). Comparing the improvement of the mucosa of the two groups of patients under gastroscopy, the total effective rate of the study group was 97.50 %, which was significantly higher than that of the control group (87.50 %, P<0.05). Conclusion: Wenneng can significantly improve the curative effect on NSAIDs-related gastric ulcer, can better improve the symptoms such as epigastric pain, abdominal distension, and lack of food, and can obviously promote the recovery of gastric mucosa. |
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