| 马 明,李嫣红,吉 锋,李 娜,谢华宁.沙库巴曲缬沙坦联合小剂量美托洛尔治疗中青年高血压的临床观察[J].,2021,(1):193-196 |
| 沙库巴曲缬沙坦联合小剂量美托洛尔治疗中青年高血压的临床观察 |
| Clinical Observation of Sacubitril Valsartan Vombined with Small Dose Metop -rolol Tartrate in the Treatment of Hypertension in Young and Middle-aged Patients |
| 投稿时间：2020-05-28 修订日期：2020-06-23 |
| DOI：10.13241/j.cnki.pmb.2021.01.043 |
| 中文关键词: 沙库巴曲缬沙坦 美托洛尔 中青年高血压 临床疗效 |
| 英文关键词: Sacubitril valsartan Metop -rolol Tartrate Youth and middle-aged hypertension Clinical efficacy |
| 基金项目:国家自然科学基金项目（81873176；81870514） |
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| 中文摘要: |
| 摘要 目的：观察沙库巴曲缬沙坦钠片联合小剂量美托洛尔治疗中青年高血压的临床疗效。方法：选择2018年12月-2019年12月间入院的92例中青年高血压患者，采用随机数表法将其分为试验组和对照组，每组46例。对照组口服沙库巴曲缬沙坦钠片，50 mg/次，2次/d；试验组在服用相同剂量沙库巴曲缬沙坦钠片的基础上增加服用小剂量美托洛尔12.5 mg/ 次，2次/d，两组用药时间均为8 w。治疗结束后，比较两组试验前后收缩压（systolic blood pressure，SBP）、舒张压（diastolic blood pressure，DBP）的变化情况，讨论两种治疗方法的有效性，并记录不良反应发生情况。结果：（1）试验组和对照组治疗后收缩压、舒张压较治疗前均有显著降低(P<0.05)；（2）治疗后，试验组收缩压、舒张压的数值明显低于对照组(P<0.05)；（3）试验组总有效率为97.83 %，高于对照组的73.91 % (P<0.05)；（4）两组不良反应发生率为试验组8.68 %，对照组6.51 %，无统计学差异(P>0.05)。结论：采用沙库巴曲缬沙坦联合小剂量美托洛尔治疗中青年高血压较单独服用沙库巴曲缬沙坦有更明显的临床优势，建议推广。 |
| 英文摘要: |
| ABSTRACT Objective: To observe the clinical efficacy of Sacubitril valsartan sodium tablets combined with a small dose of Metop -rolol Tartrate in the treatment of hypertension in young and middle-aged adults. Methods: A total of 92 young and middle-aged patients with hypertension from December 2018 to December 2019 were selected and divided into the experimental group and the control group by random number table method. Patients in the control group were given oral Sacubitril valsartan sodium tablets, 50 mg/ time, 2 times/day. In the experimental group, the patients were given the same dose of Metop -rolol Tartrate a small dose of betaloc, 12.5 mg/ time, 2 times/day. The duration of medication in both groups was 8 weeks.After the treatment, the changes of systolic blood pressure (SBP) and diastolic blood pressure (DBP) before and after the trial were compared between the two groups to discuss the effectiveness of the two treatment methods and record the occurrence of adverse reactions during the trial. Results: The systolic and diastolic blood pressure in two groups were significantly lower after treatment than before treatment (P<0.05). After treatment, the values of systolic and diastolic blood pressure in the experimental group were significantly lower than those in the control group (P<0.05). The total effective rate of the experimental group was 98.23 %, which was higher than that of the control group (75.00 %, P<0.05). The incidence of adverse reactions between the two groups was the experimental group 9.23 % and the control group 6.53 %, with not statistically significant (P>0.05). Conclusion: The combination of Sacubitril valsartan and small dose Metop -rolol Tartrate in the treatment of hypertension in young and middle-aged people has more obvious clinical advantages than that of Sacubitril valsartan alone. |
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