| 毛甜甜,黄 丽,彭若冰,刘林花,彭友俭.盐酸米诺环素软膏辅助龈下刮治术及根面平整术对慢性牙周炎患者龈下牙周致病菌和龈沟液炎性因子的影响[J].,2021,(4):650-653 |
| 盐酸米诺环素软膏辅助龈下刮治术及根面平整术对慢性牙周炎患者龈下牙周致病菌和龈沟液炎性因子的影响 |
| Effects of Minocycline Hydrochloride Ointment Assisted Subgingival Scaling and Root Planing on Subgingival Periodontal Pathogens and Gingival Crevicular Fluid Inflammatory Factors in Patients with Chronic Periodontitis |
| 投稿时间：2020-09-06 修订日期：2020-09-30 |
| DOI：10.13241/j.cnki.pmb.2021.04.010 |
| 中文关键词: 盐酸米诺环素软膏 龈下刮治术 根面平整术 慢性牙周炎 牙周致病菌 炎性因子 |
| 英文关键词: Minocycline hydrochloride ointment Subgingival scaling Root planing Chronic periodontitis Periodontal pathogens Inflammatory factors |
| 基金项目:湖北省卫生计生委科研基金项目(WJ2017F069) |
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| 中文摘要: |
| 摘要 目的：探讨盐酸米诺环素软膏辅助龈下刮治术及根面平整术（FM-SRP）对慢性牙周炎（CP）患者龈下牙周致病菌和龈沟液炎性因子的影响。方法：选择2015年10月到2019年10月期间我院收治的82例CP患者，根据随机数字表法分为对照组（n=41）和观察组（n=41），对照组给予FM-SRP，观察组在对照组基础上联合盐酸米诺环素软膏辅助治疗，比较两组疗效、牙周指标、龈下牙周致病菌和龈沟液炎性因子情况，统计两组不良反应情况。结果：与对照组总有效率70.73%（29/41）相比，观察组治疗后的总有效率90.24%（37/41）更高（P＜0.05）。治疗后，两组龈沟出血指数（SBI）、附着水平（AL）、菌斑指数（PLI）、牙周袋深度（PD）均下降，且观察组低于对照组（P＜0.05）。治疗后，两组转化生长因子-β（TGF-β）、白介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）均下降，且观察组低于对照组（P＜0.05）。对比两组不良反应无差异（P＞0.05）。治疗后，两组伴防线杆菌、牙龈卟啉单胞菌比例均下降，且观察组低于对照组（P＜0.05）。结论：盐酸米诺环素软膏辅助FM-SRP治疗CP患者，可有效消除致病菌，缓解炎性反应，恢复牙周生态平衡，且不增加不良反应发生率，疗效确切。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effects of minocycline hydrochloride ointment assisted subgingival scaling and root planing (FM-SRP) on subgingival periodontal pathogens and gingival crevicular fluid inflammatory factors in patients with chronic periodontitis (CP). Methods: A total of 82 patients with CP who were admitted to our hospital from October 2015 to October 2019 were selected, they were divided into control group (n=41) and observation group (n=41) according to random number table method. The control group was given FM-SRP, and the observation group was treated with minocycline hydrochloride ointment on the basis of the control group. The efficacy, periodontal indexes, subgingival periodontal pathogens and gingival crevicular fluid inflammatory factors were compared between the two groups, the adverse reactions of the two groups were counted. Results: Compared with the total effective rate of 70.73%（29/41）in the control group, the total effective rate of 90.24%（37/41）in the observation group after treatment was higher (P<0.05). After treatment, The sulcus bleeding index (SBI), attachment level (AL), plaque index (PLI) and periodontal pocket depth (PD) of the two groups decreased, and the observation group was lower than the control group(P<0.05). After treatment, the transforming growth factor-β (TGF-β), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) levels of the two groups decreased, and the observation group was lower than the control group (P<0.05). There was no difference in adverse reactions between the two groups (P>0.05). After treatment, the proportion of Bacillus parahaemolyticus and Porphyromonas gingivalis decreased in both groups, and the observation group was lower than the control group (P<0.05). Conclusion: Minocycline hydrochloride ointment assisted FM-SRP in the treatment of patients with CP can effectively eliminate the pathogenic bacteria, alleviate the inflammatory reaction, restore the periodontal ecological balance, and does not increase the incidence of adverse reactions, with definite curative effect. |
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