| 王明霞,魏锦锦,张 梅,戴大飞,王艾君.早期康复对ICU获得性肌无力患者肌力改善、细胞免疫因子及睡眠质量的影响[J].,2021,(4):759-763 |
| 早期康复对ICU获得性肌无力患者肌力改善、细胞免疫因子及睡眠质量的影响 |
| Effect of Early Rehabilitation on Muscle Strength Improvement, Cellular Immune Factors and Sleep Quality in Patients with Intensive Care Unit-Acquired Weakness |
| 投稿时间：2020-07-27 修订日期：2020-08-23 |
| DOI：10.13241/j.cnki.pmb.2021.04.034 |
| 中文关键词: 早期康复 ICU获得性肌无力 肌力改善 细胞免疫因子 睡眠质量 |
| 英文关键词: Early rehabilitation Intensive Care Unit-Acquired Weakness Muscle strength Cellular immune factors Sleep quality |
| 基金项目:安徽省卫生计生委科研计划项目（2016QK1037）；皖南医学院中青年科研基金项目（WK2019F02） |
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| 中文摘要: |
| 摘要 目的：探讨早期康复对ICU获得性肌无力（ICU-AW）患者肌力改善、细胞免疫因子及睡眠质量的影响。方法：纳入2017年1月～2020年8月我院收治的ICU-AW患者146例，依照随机数字表法分为观察组（n=73）和对照组（n=73）。对照组给予常规干预，观察组给予常规干预联合早期康复。康复前后，考察两组肌力改善、气道阻塞、睡眠情况及血清CD3+、CD4+、CD8+、CD4+/CD8+水平。结果：观察组康复后各项肌力得分、各项PSQI评分均低于对照组，差异均有统计学意义（P＜0.05）。观察组康复后中心气道、周围气道阻塞比例均低于对照组，差异均有统计学意义（P＜0.05）。观察组康复后血清CD3+、CD4+、CD4+/CD8+水平均低于对照组，CD8+水平高于对照组，差异均有统计学意义（P＜0.05）。结论：早期康复可有效改善ICU-AW患者肌力，缓解气道阻塞，纠正细胞免疫因子失衡，提高睡眠质量，值得临床推荐。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of early rehabilitation on muscle strength improvement, cellular immune factors and sleep quality in patients with Intensive Care Unit-Acquired Weakness(ICU-AW). Methods: 146 patients with ICU-AW admitted to our hospital from January 2017 to August 2020 were selected and randomly divided into observation group (n=73) and control group (n=73). The control group was given routine intervention, and the observation group was given routine intervention combined with early rehabilitation. Before and after rehabilitation, the improvement of muscle strength, airway obstruction, sleep status and serum levels of CD3+, CD4+, CD8+, CD4+/CD8+ were observed. Results: The scores of muscle strength and PSQI score in the observation group after rehabilitation were lower than those in the control group, and the differences were statistically significant (P<0.05). The proportion of central airway and peripheral airway obstruction in the observation group after rehabilitation was lower than that in the control group, and the differences were statistically significant (P<0.05). The levels of serum CD3+, CD4+, CD4+/CD8+ in the observation group after rehabilitation were lower than those in the control group, and the level of CD8+ in the observation group was higher than that in the control group, the differences were statistically significant(P<0.05). Conclusion: Early rehabilitation can effectively improve the muscle strength of ICU-AW patients, relieve airway obstruction, correct the imbalance of cellular immune factors, and improve sleep quality, which is worthy of clinical recommendation. |
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