| 程如焕,邹绍静,王 兵,王兆清,张玉莲,王昌成.血清P53、MMP-7抗体表达与食管癌的病理类型、分期的相关性[J].,2021,(5):927-931 |
| 血清P53、MMP-7抗体表达与食管癌的病理类型、分期的相关性 |
| Correlation of Serum P53, MMP-7 antibody Expression with Pathological Type, Stage of Esophageal Cancer |
| 投稿时间：2020-08-05 修订日期：2020-08-28 |
| DOI：10.13241/j.cnki.pmb.2021.05.027 |
| 中文关键词: 食管癌 P53 基质金属蛋白酶-7 病理类型 临床分期 |
| 英文关键词: Esophageal cancer P53 Matrix metalloproteinase-7 Pathological type Clinical stage |
| 基金项目:国家自然科学基金青年基金项目(81502038) |
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| 中文摘要: |
| 摘要 目的：探讨血清P53、基质金属蛋白酶-7(Matrix metalloproteinase-7，MMP-7)抗体表达与食管癌的病理类型、分期的相关性。方法：2019年10月-2020年4月选择在本院诊治的食管癌患者80例作为食管癌组，同期选择体检的健康人50例作为对照组，检测两组血清P53、MMP-7抗体表达情况，调查患者的临床病理资料并进行相关性分析。结果：食管癌组的血清P53、MMP-7抗体滴度及阳性率分别明显高于对照组，差异均有统计学意义（P<0.05）。 在食管癌组中，不同临床分期、组织分化程度、淋巴结转移、肿瘤大小患者的P53、MMP-7抗体滴度及表达阳性率对比差异有统计学意义(P<0.05)。Spearman秩相关检验分析显示P53、MMP-7抗体表达与临床分期都存在相关性，与临床病理类型不存在相关性(P<0.05)。Cox多因素分析显示临床分期、组织分化程度、淋巴结转移、肿瘤大小都为影响血清P53、MMP-7抗体表达的主要因素(P<0.05)。P53、MMP-7抗体指标进行ROC曲线分析，P53曲线下面积为0.804，敏感性90.0 %，特异性为60.0 %，MMP-7曲线下面积为0.835，敏感性97.2 %，特异性为62.5 %。结论：食管癌患者中血清P53、MMP-7呈现高表达状况，与患者的临床分期都存在相关性，与临床病理类型不存在相关性，临床分期、组织分化程度、淋巴结转移、肿瘤大小都为影响血清P53、MMP-7抗体表达的主要因素，二者的诊断敏感性高。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the correlation between serum P53, Matrix metalloproteinase-7 (MMP-7) antibody expression and the pathological type, stage of esophageal cancer. Methods: A total of 80 patients with esophageal cancer,who were diagnosed and treated in Huai'an Second People's Hospital from October 2019 to April 2020, were chosen as esophageal cancer group; 50 healthy people with physical examination were chosen as control group during the same period. The expression of serum P53 and MMP-7 antibody was detected in the two groups. The clinicopathological data of the patients were investigated and were performed a correlation analysis. Results: The serum P53 and MMP-7 antibody titers and positive rates of the esophageal cancer group were significantly higher than those of the control group, and the differences were statistically significant (P<0.05). In the esophageal cancer group, the differences in P53, MMP-7 antibody titers and positive expression rates among the patients with different clinical stages, tissue differentiation, lymph node metastasis, tumor size were statistically significant (P<0.05). Spearman rank correlation test analysis showed that the expression of P53 and MMP-7 antibodies were correlated with the clinical stage, and were not correlated with the clinical pathological type (P<0.05). Cox multivariate analysis showed that clinical stage, tissue differentiation, lymph node metastasis, and tumor size were the main factors affected the expression of serum P53 and MMP-7 antibodies (P<0.05). P53 and MMP-7 antibody indexes were analyzed by ROC curve. The area under the P53 curve was 0.804, with a sensitivity of 90.0% and a specificity of 60.0%. The area under the MMP-7 curve was 0.835, with a sensitivity of 97.2% and a specificity of 62.5%. Conclusion: Serum P53 and MMP-7 are highly expressed in the patients with esophageal cancer, which are correlated with the clinical stage of the patients, but not correlated with the clinical pathological type. The clinical stage, tissue differentiation, lymph node metastasis, and tumor size are the main factors affected the expression of serum P53 and MMP-7 antibodies, and both have high diagnostic sensitivity. |
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