| 牛 静,孙 金,张 迪,任 茜,周 伦,武倩雯,马忠英.黄芩苷对慢性萎缩性胃炎模型鼠OPG/RANKL轴的影响[J].,2021,(8):1434-1437 |
| 黄芩苷对慢性萎缩性胃炎模型鼠OPG/RANKL轴的影响 |
| Effects of Baicalin on OPG/RANKL Axis of Chronic Atrophic Gastritis Model Rats |
| 投稿时间：2020-10-09 修订日期：2020-10-31 |
| DOI：10.13241/j.cnki.pmb.2021.08.007 |
| 中文关键词: 黄芩苷 慢性萎缩性胃炎 大鼠 OPG/RANKL轴 氧化应激 |
| 英文关键词: Baicalin Chronic atrophic gastritis Rats OPG/RANKL axis Oxidative stress |
| 基金项目:陕西省重点研发计划项目（2019-SF-219） |
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| 中文摘要: |
| 摘要 目的：探讨黄芩苷对慢性萎缩性胃炎模型鼠OPG/RANKL轴的影响。方法：将建模成功的大鼠(n=42)平分为三组-模型组、雷尼替丁组与黄芩苷组，黄芩苷组灌胃6.3 g/kg体重的黄芩苷溶液(5 mg?kg-1)，雷尼替丁组灌胃6.3 g/kg体重的雷尼替丁生理盐水溶液(150 mg?kg-1)，模型组灌胃与同容积的生理盐水，记录不同时间点OPG/RANKL轴表达变化情况。结果：雷尼替丁组与黄芩苷组治疗后2 w与4 w的体重高于模型组(P<0.05)，黄芩苷组高于雷尼替丁组(P<0.05)。雷尼替丁组与黄芩苷组治疗后2 w与4 w的胃黏膜组织评分低于模型组(P<0.05)，黄芩苷组低于雷尼替丁组(P<0.05)。雷尼替丁组与黄芩苷组治疗后2 w与4 w的血清NO与SOD含量高于模型组(P<0.05)，黄芩苷组高于雷尼替丁组(P<0.05)。雷尼替丁组与黄芩苷组治疗后2 w与4 w的胃窦组织OPG、RANKL蛋白相对表达水平高于对照组，黄芩苷组高于雷尼替丁组(P<0.05)。结论：黄芩苷治疗慢性萎缩性胃炎模型鼠能激活OPG/RANKL轴，提高血清NO与SOD含量，能减少胃黏膜组织损伤，提高大鼠体重。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effects of baicalin on OPG/RANKL axis of chronic atrophic gastritis model mice. Methods: The successfully modeled rats (n=42) were equally divided into three groups-model group, ranitidine group and baicalin group. Baicalin group was given intragastrically 6.3 g/kg baicalin solution (5 mg?kg-1); the ranitidine group was given intragastrically with 6.3 g/kg body weight ranitidine saline solution (150 mg?kg-1); the model group was given intragastrically with the same volume of saline solution.OPGRANKL axis expression changes were recorded at different time points. Results: The body weight of the ranitidine group and the baicalin group were higher than that of the model group 2 and 4 weeks after treatment(P<0.05), and the baicalin group was higher than the ranitidine group (P<0.05). The gastric mucosal tissue scores of the ranitidine group and the baicalin group were lower than the model group 2 and 4 weeks after treatment(P<0.05), and the baicalin group was lower than the ranitidine group(P<0.05). The serum NO and SOD levels of the ranitidine group and the baicalin group were higher than those of the model group 2 and 4 weeks after treatment(P<0.05), and the baicalin group was higher than the ranitidine group(P<0.05). The relative expression levels of OPG and RANKL protein in gastric antrum tissue in the ranitidine group and the baicalin group were higher than those in the model group 2 and 4 weeks after treatment(P<0.05), and the baicalin group was higher than the ranitidine group(P<0.05). Conclusion: In the treatment of chronic atrophic gastritis model mice, baicalin can activate OPG/RANKL axis, increase serum NO and SOD content, reduce gastric mucosal tissue damage, and increase rat body weight. |
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