文章摘要
牛 静,孙 金,张 迪,任 茜,周 伦,武倩雯,马忠英.黄芩苷对慢性萎缩性胃炎模型鼠OPG/RANKL轴的影响[J].,2021,(8):1434-1437
黄芩苷对慢性萎缩性胃炎模型鼠OPG/RANKL轴的影响
Effects of Baicalin on OPG/RANKL Axis of Chronic Atrophic Gastritis Model Rats
投稿时间:2020-10-09  修订日期:2020-10-31
DOI:10.13241/j.cnki.pmb.2021.08.007
中文关键词: 黄芩苷  慢性萎缩性胃炎  大鼠  OPG/RANKL轴  氧化应激
英文关键词: Baicalin  Chronic atrophic gastritis  Rats  OPG/RANKL axis  Oxidative stress
基金项目:陕西省重点研发计划项目(2019-SF-219)
作者单位E-mail
牛 静 中国人民解放军空军军医大学第一附属医院 药剂科 陕西 西安 710032 niujing202007@163.com 
孙 金 中国人民解放军空军军医大学第一附属医院 药剂科 陕西 西安 710032  
张 迪 中国人民解放军空军军医大学第一附属医院 药剂科 陕西 西安 710032  
任 茜 中国人民解放军空军军医大学第一附属医院 药剂科 陕西 西安 710032  
周 伦 中国人民解放军空军军医大学第一附属医院 药剂科 陕西 西安 710032  
武倩雯 中国人民解放军空军军医大学第一附属医院 药剂科 陕西 西安 710032  
马忠英 中国人民解放军空军军医大学第一附属医院 药剂科 陕西 西安 710032  
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中文摘要:
      摘要 目的:探讨黄芩苷对慢性萎缩性胃炎模型鼠OPG/RANKL轴的影响。方法:将建模成功的大鼠(n=42)平分为三组-模型组、雷尼替丁组与黄芩苷组,黄芩苷组灌胃6.3 g/kg体重的黄芩苷溶液(5 mg?kg-1),雷尼替丁组灌胃6.3 g/kg体重的雷尼替丁生理盐水溶液(150 mg?kg-1),模型组灌胃与同容积的生理盐水,记录不同时间点OPG/RANKL轴表达变化情况。结果:雷尼替丁组与黄芩苷组治疗后2 w与4 w的体重高于模型组(P<0.05),黄芩苷组高于雷尼替丁组(P<0.05)。雷尼替丁组与黄芩苷组治疗后2 w与4 w的胃黏膜组织评分低于模型组(P<0.05),黄芩苷组低于雷尼替丁组(P<0.05)。雷尼替丁组与黄芩苷组治疗后2 w与4 w的血清NO与SOD含量高于模型组(P<0.05),黄芩苷组高于雷尼替丁组(P<0.05)。雷尼替丁组与黄芩苷组治疗后2 w与4 w的胃窦组织OPG、RANKL蛋白相对表达水平高于对照组,黄芩苷组高于雷尼替丁组(P<0.05)。结论:黄芩苷治疗慢性萎缩性胃炎模型鼠能激活OPG/RANKL轴,提高血清NO与SOD含量,能减少胃黏膜组织损伤,提高大鼠体重。
英文摘要:
      ABSTRACT Objective: To investigate the effects of baicalin on OPG/RANKL axis of chronic atrophic gastritis model mice. Methods: The successfully modeled rats (n=42) were equally divided into three groups-model group, ranitidine group and baicalin group. Baicalin group was given intragastrically 6.3 g/kg baicalin solution (5 mg?kg-1); the ranitidine group was given intragastrically with 6.3 g/kg body weight ranitidine saline solution (150 mg?kg-1); the model group was given intragastrically with the same volume of saline solution.OPGRANKL axis expression changes were recorded at different time points. Results: The body weight of the ranitidine group and the baicalin group were higher than that of the model group 2 and 4 weeks after treatment(P<0.05), and the baicalin group was higher than the ranitidine group (P<0.05). The gastric mucosal tissue scores of the ranitidine group and the baicalin group were lower than the model group 2 and 4 weeks after treatment(P<0.05), and the baicalin group was lower than the ranitidine group(P<0.05). The serum NO and SOD levels of the ranitidine group and the baicalin group were higher than those of the model group 2 and 4 weeks after treatment(P<0.05), and the baicalin group was higher than the ranitidine group(P<0.05). The relative expression levels of OPG and RANKL protein in gastric antrum tissue in the ranitidine group and the baicalin group were higher than those in the model group 2 and 4 weeks after treatment(P<0.05), and the baicalin group was higher than the ranitidine group(P<0.05). Conclusion: In the treatment of chronic atrophic gastritis model mice, baicalin can activate OPG/RANKL axis, increase serum NO and SOD content, reduce gastric mucosal tissue damage, and increase rat body weight.
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