文章摘要
姚士伟,李 静,郭秀丽,贾 雷,王 晓.奥沙利铂和氟尿嘧啶联合贝伐珠单抗对晚期胃癌患者免疫功能、肿瘤标志物和预后的影响[J].,2021,(8):1452-1455
奥沙利铂和氟尿嘧啶联合贝伐珠单抗对晚期胃癌患者免疫功能、肿瘤标志物和预后的影响
Effects of Oxaliplatin and Fluorouracil Combined with Bevacizumab on Immune Function, Tumor Markers and Prognosis in Patients with Advanced Gastric Cancer
投稿时间:2020-11-04  修订日期:2020-11-27
DOI:10.13241/j.cnki.pmb.2021.08.011
中文关键词: 奥沙利铂  氟尿嘧啶  贝伐珠单抗  晚期  胃癌  免疫功能  肿瘤标志物  预后
英文关键词: Oxaliplatin  Fluorouracil  Bevacizumab  Advanced stage  Gastric cancer  Immune function  Tumor markers  Prognosis
基金项目:北京市优秀人才培养资助项目(2017000021469G217)
作者单位E-mail
姚士伟 首都医科大学附属北京天坛医院消化内科 北京 100070 ysw7722@163.com 
李 静 首都医科大学附属北京天坛医院消化内科 北京 100070  
郭秀丽 首都医科大学附属北京天坛医院消化内科 北京 100070  
贾 雷 首都医科大学附属北京天坛医院消化内科 北京 100070  
王 晓 首都医科大学附属北京天坛医院消化内科 北京 100070  
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中文摘要:
      摘要 目的:探讨奥沙利铂和氟尿嘧啶联合贝伐珠单抗对晚期胃癌患者免疫功能、肿瘤标志物和预后的影响。方法:选取2014年3月到2017年5月期间我院收治的晚期胃癌患者62例,根据住院号单双数分为对照组和观察组,各31例。对照组给予奥沙利铂和氟尿嘧啶治疗,观察组在对照组的基础上联合贝伐珠单抗治疗,对比两组临床有效率、免疫功能、肿瘤标志物、不良反应和预后。结果:观察组治疗后的临床有效率较对照组高(P<0.05)。两组治疗后免疫球蛋白(Ig)A、IgG、CD4+/CD8+、CD4+、IgM均升高,且观察组高于对照组(P<0.05),两组治疗后CD8+均降低,且观察组低于对照组(P<0.05)。两组治疗后癌胚抗原( CEA) 、糖类抗原199(CA199)、糖类抗原72-4(CA72-4)均降低,且观察组低于对照组(P<0.05)。观察组的不良反应总发生率较对照组低(P<0.05)。观察组复发率、癌症转移率低于对照组,且3年生存率高于对照组(P<0.05)。结论:奥沙利铂和氟尿嘧啶联合贝伐珠单抗治疗晚期胃癌患者,可有效缓解病情,提高免疫功能,同时还降低不良反应发生率,获得良好的预后。
英文摘要:
      ABSTRACT Objective: To investigate the effect of oxaliplatin and fluorouracil combined with bevacizumab on immune function, tumor markers and prognosis in patients with advanced gastric cancer. Methods: 62 patients with advanced gastric cancer in our hospital from March 2014 to May 2017 were selected, and they were divided into control group and observation group according to even and odd of admission number, 31 cases in each group. The control group was treated with oxaliplatin and fluorouracil, and the observation group was treated with bevacizumab on the basis of the control group. The effective rate, immune function, tumor markers, adverse reactions and prognosis of the two groups were compared. Results: The clinical effective rate of the observation group was higher than that of the control group (P<0.05). After treatment, immunoglobulin (Ig)A, IgG, CD4+/CD8+, CD4+, IgM of the two groups were increased, and the observation group was higher than the control group(P<0.05). After treatment, CD8+ of the two groups was decreased, and the observation group was lower than the control group(P<0.05). After treatment, carcinoembryonic antigen (CEA), carbohydrate antigen 199 (CA199), carbohydrate antigen 72-4 (CA72-4) of the two groups decreased, but the observation group was higher than the control group (P<0.05). The total incidence of adverse reactions of the observation group was lower than that of the control group(P<0.05). The recurrence rate, cancer metastasis rate of the observation group was lower than those of the control group and 3-year survival rate was higher than that of the control group(P<0.05). Conclusion: Fluorouracil, oxaliplatin combined with bevacizumab in the treatment of patients with advanced gastric cancer, can effectively prevent disease progression, can improve immune function, but also reduce the incidence of adverse reactions, to obtain a good prognosis.
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