文章摘要
林 楠,许子琪,蔡 雁,贾长茹,孙思维,陈巧玲.miR-23a在宫颈癌患者组织血清中的表达及相关性分析[J].,2021,(8):1507-1510
miR-23a在宫颈癌患者组织血清中的表达及相关性分析
Expression and Correlation Analysis of miR-23a in Serum of Patients with Cervical Cancer
投稿时间:2020-08-23  修订日期:2020-09-18
DOI:10.13241/j.cnki.pmb.2021.08.023
中文关键词: 宫颈癌  miR-23a  早期诊断
英文关键词: Cervical cancer  miR-23a  Early diagnosis
基金项目:黑龙江省自然科学基金联合引导项目(LH2019H078);黑龙江省大学生创新创业训练项目(201910226038)
作者单位
林 楠 哈尔滨医科大学附属第四医院妇产科 黑龙江 哈尔滨 150001 
许子琪 哈尔滨医科大学附属第四医院妇产科 黑龙江 哈尔滨 150001 
蔡 雁 哈尔滨医科大学附属第四医院妇产科 黑龙江 哈尔滨 150001 
贾长茹 哈尔滨医科大学附属第四医院妇产科 黑龙江 哈尔滨 150001 
孙思维 哈尔滨医科大学附属第四医院妇产科 黑龙江 哈尔滨 150001 
陈巧玲 哈尔滨医科大学附属第四医院妇产科 黑龙江 哈尔滨 150001 
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中文摘要:
      摘要 目的:探讨宫颈癌患者血清中miR-23a的表达及与患者预后转归的相关性分析。方法:选取在我院进行手术治疗的120例宫颈癌患者为观察组,120例宫颈活检结果正常者为对照组。观察手术前及手术后患者血清中miR-23a的表达,肿瘤标志物及炎性因子含量变化,并分析miR-23a表达与宫颈癌患者临床病理特征的关系及预后。结果:观察组患者术前血清中miR-23a的相对表达量明显高于对照组miR-23a的相对量,差异具有统计学意义(P<0.05)。与手术前比较,术后观察组血清中miR-23a的相对量明显降低,肿瘤标志物癌抗原125(Cancer antigen 125, CA125)及鳞状上皮细胞癌抗原(Squamous cell carcinoma antigen, SCCA)含量明显降低,白细胞介素-6(Interleukin-6,IL-6)、肿瘤坏死因子-α(Tumor necrosis factor-α,TNF-α)及C反应白蛋白(C reactive protein, CRP)水平含量亦明显降低,差异具有统计学意义(P<0.05)。观察组120例宫颈癌患者有74例miR-23a高表达,46例为miR-23a低表达。观察组患者血清中高表达miR-23a含量变化与妇科疾病史,肿瘤直径,淋巴结转移,肿瘤分化程度有关,差异具有统计学意义(P<0.05)。观察组患者miR-23a高表达患者生存期明显少于miR-23a低表达患者(P<0.05)。结论:血清中miR-23a高表达可能是判断宫颈癌预后的重要标志物。
英文摘要:
      ABSTRACT Objective: To investigate the expression of miR-23a in serum of patients with cervical cancer and its correlation with prognosis. Methods: 120 patients with cervical cancer who underwent surgical treatment in our hospital were selected as observation group and 120 patients with normal cervical biopsies as control group. Observe the expression of miR-23a, the changes of tumor markers and inflammatory factors in the serum of patients before and after surgery, and analyze the relationship between the expression of miR-23a and the clinicopathological characteristics and prognosis of cervical cancer patients. Results: The relative expression of miR-23a in serum of the observation group was significantly higher than that of the control group(P<0.05). Compared with before operation, the relative amount of miR-23a in serum, the content of CA1225 and SCCA, the level of inflammatory factor IL-6, TNF-α and CRP in the observation group were significantly lower than those before operation, the difference was statistically significant (P<0.05). There were 74 cases with high expression of miR-23a and 46 cases with low expression of miR-23a in 120 patients with cervical cancer in the observation group. The changes of high expression of miR-23a in the serum of the observation group were related to the history of gynecological diseases, tumor diameter, lymphatic metastasis and the degree of tumor differentiation, and the difference was statistically significant (P<0.05). The survival time of patients with high expression of miR-23a in observation group was significantly lower than that in patients with low expression of miR-23a(P<0.05). Conclusion: The high expression of miR-23a in serum may be an important marker to judge the prognosis of cervical cancer.
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