| 周 云,李 瑾,刘音吟,季 静,马蔚蓉.气滞痛经汤联合散结镇痛胶囊治疗原发性痛经应用效果及安全性[J].,2021,(9):1714-1718 |
| 气滞痛经汤联合散结镇痛胶囊治疗原发性痛经应用效果及安全性 |
| Effect of Qizhi Tongjing Decoction Combined with Sanjie Zhentong Capsule on Primary Dysmenorrhea |
| 投稿时间：2020-11-02 修订日期：2020-11-25 |
| DOI：10.13241/j.cnki.pmb.2021.09.025 |
| 中文关键词: 气滞痛经汤 散结镇痛胶囊 原发性痛 安全性 |
| 英文关键词: Qizhi Tongjing Decoction Sanjie Zhentong capsule Primary pain Safety |
| 基金项目:国家卫生计生委医药卫生科技发展项目( W2015CAE173) |
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| 中文摘要: |
| 摘要 目的：探讨气滞痛经汤联合散结镇痛胶囊治疗原发性痛经应用效果及安全性。方法：选取我院2018年1月到2020年1月共收治的80例原发性痛经患者，按照随机数字法将所有患者均分为对照组（40例）和观察组（40例）。针对于不同组别患者应用不同的治疗方法，其中对照组应用散结镇痛胶囊口服治疗，观察组应用气滞痛经汤联合散结镇痛胶囊口服治疗，对比两组的治疗效果、治疗前后盆腔血流搏动指数(pulsatility index，PI)和阻抗指数(resistive index，RI)、治疗前后的疼痛持续时间、痛经评分、视觉模拟评分（visual analogue scale，VAS）以及不良反应发生率。结果：观察组的治疗总有效率为95.0 %，对照组的治疗总有效率为77.5 %，观察组明显高于对照组（P＜0.05）；两组治疗前左侧PI、右侧PI、左侧RI和右侧RI指标水平对比无明显差异（P＞0.05），两组治疗后左侧PI、右侧PI、左侧RI和右侧RI指标水平对比差异显著，观察组明显低于对照组（P＜0.05）；两组治疗前疼痛持续时间、痛经评分和VAS评分对比无显著差异（P＞0.05），两组治疗后三项疼痛指标评分较治疗前显著降低，且观察组低于对照组（P＜0.05）；比较两组的不良反应发生率，观察组（10.0 %）略高于对照组（5.0 %），对比无显著差异（P＞0.05）。结论：对原发性痛经患者应用气滞痛经汤联合散结镇痛胶囊治疗，能够减轻患者的临床症状，降低双侧子宫脉血流动力学变化，降低患者的痛经程度，安全性好，值得临床应用推广。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect and safety of Qizhi Tongjing decoction combined with Sanjie Zhentong capsule in the treatment of primary dysmenorrhea. Methods: A total of 80 patients with primary dysmenorrhea,who were treated in Jiangsu Provincial Hospital of Traditional Chinese Medicine from January 2018 to January 2020, were chosen as research subjects and were randomly divided into observation group(40 cases) and control group (40 cases). The control group was given Sanjie Zhentong capsule; the observation group, Qizhi Tongjing decoction combined with Sanjie Zhentong capsule. The treatment effect, pulsatility index(PI) and resistive index (RI) of pelvic blood flow, pain duration t, dysmenorrhea score, VAS score before and after treatmen and incidence of adverse reactions were compared between the two groups. Results: The total effective rate (95.0%) of the observation group was significantly higher than that(77.5 %) of the control group(P<0.05). There were no significant differences in the left PI, right PI, left RI and right RI before treatment between the two groups(P>0.05); there were significant differences in the left PI, right PI, left RI and right RI between the two groups, and the observation group was significantly lower than the control group(P<0.05). There was no significant difference in the pain duration, dysmenorrhea score and VAS score between the two groups(P>0.05). The scores of the three indexes of the two groups after treatment were significantly lower than those before treatment, and the observation group was lower than the control group(P<0.05). The incidence of adverse reactions in the observation group (10.0%) was slightly higher than that (5.0 %) in the control group, with no significant difference(P>0.05). Conclusion: The application of Qizhi Tongjing decoction combined with Sanjie Zhentong capsule in the treatment of patients with primary dysmenorrhea can reduce the clinical symptoms of patients, the hemodynamic changes of bilateral uterine veins, and the degree of dysmenorrhea of patients, with good safety, which is worthy of clinical application and promotion. |
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