| 金 麟,褚云香,翁 艳,贾志伟,刘晓川,王东盛.复方猴头胶囊联合替普瑞酮对胃溃疡患者胃肠激素、炎性因子及胃窦黏膜TGF-β、Smad3表达的影响[J].,2021,(9):1781-1785 |
| 复方猴头胶囊联合替普瑞酮对胃溃疡患者胃肠激素、炎性因子及胃窦黏膜TGF-β、Smad3表达的影响 |
| Effect of Compound Houtou Capsule Combined with Teprenone on Gastrointestinal Hormones, Inflammatory Factors and Expression of TGF-β and Smad3 in Patients with Gastric Ulcer |
| 投稿时间：2021-01-03 修订日期：2021-01-25 |
| DOI：10.13241/j.cnki.pmb.2021.09.040 |
| 中文关键词: 复方猴头胶囊 替普瑞酮 胃溃疡 胃肠激素 炎性因子 TGF-β Smad3 |
| 英文关键词: Compound Houtou capsule Teprenone Gastric ulcer Gastrointestinal hormone Inflammatory factor TGF-β Smad3 |
| 基金项目:北京市科学技术委员会支持项目（D14110004002） |
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| 摘要 目的：探讨复方猴头胶囊联合替普瑞酮对胃溃疡患者胃肠激素、炎性因子及胃窦黏膜转化生长因子-β（TGF-β）、信号转导蛋白3（Smad3）表达的影响。方法：选取2017年1月~2020年1月期间我院收治的胃溃疡患者120例，按信封抽签法分为观察组和对照组各60例。两组均给予艾司奥美拉唑口服，在此基础上对照组给予替普瑞酮治疗，观察组给予复方猴头胶囊联合替普瑞酮治疗。观察两组治疗前后的胃肠激素、炎性因子及胃窦黏膜TGF-β、Smad3表达的变化情况。比较两组溃疡愈合情况、不良反应发生率和复发率。结果：与对照组相比，观察组溃疡愈合总有效率更高（P<0.05）。两组治疗后胃动素（MTL）、胃泌素（GAS）、C-反应蛋白（CRP）、白介素-6（IL-6）、白介素-8（IL-8）水平均较治疗前下降，且观察组低于对照组（P<0.05）。治疗后，两组TGF-β、Smad3表达较治疗前降低（P<0.05），且观察组TGF-β、Smad3表达低于对照组（P<0.05）。观察组复发率明显低于对照组（P<0.05），但两组不良反应发生率比较无明显差异（P>0.05）。结论：复方猴头胶囊联合替普瑞酮能明显改善胃溃疡患者胃肠激素、炎性因子水平，降低胃窦黏膜中TGF-β、Smad3的表达，促进溃疡愈合，同时安全性良好，患者复发率低。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of compound Houtou capsule combined with teprenone on gastrointestinal hormones, inflammatory factors and expression of transforming growth factor-β(TGF-β) and Smad3 in patients with gastric ulcer. Methods: 120 patients with gastric ulcer who were treated in our hospital from January 2017 to January 2020 were selected. According to the method of envelope lottery, they were randomly divided into observation group and control group with 60 cases in each group. Both groups were given esomeprazole orally. On this basis, the control group was treated with tepreidone, and the observation group was given compound Houtou capsule combined with teprenone. The changes of gastrointestinal hormones, inflammatory factors and the expression of TGF-β and Smad3 in gastric antral mucosa of the two groups were observed before and after treatment. The ulcer healing, adverse reaction rate and recurrence rate were compared between the two groups. Results: The total effective rate of ulcer healing of the observation group were significantly higher than those of the control group, the difference was statistically significant (P<0.05). After treatment, the levels of motilin (MTL), gastrin (GAS), C-reactive protein (CRP), interleukin-6 (IL-6) and interleukin-8 (IL-8) of the two groups were all lower than those before treatment, and the levels of the above indicators of the observation group were lower than those of the control group (P<0.05). After treatment, the expression levels of TGF-β and Smad3 of the two groups were decreased compared with those before treatment (P<0.05), and the expressions of TGF-β and Smad3 of the observation group were lower than those of the control group (P<0.05). The recurrence rate of the observation group was significantly lower than that of the control group (P<0.05), but there was no significant difference in the incidence rate of adverse reactions between the two groups (P>0.05). Conclusion: Compound Houtou capsule combined with teprenone can significantly improve the levels of gastrointestinal hormones and inflammatory factors in patients with gastric ulcer, reduce the expression of TGF-β and Smad3 in gastric antral mucosa, promote ulcer healing, and have good safety and low recurrence rate. |
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