| 贺荣荣,樊阳阳,张莉莉,袁晓华,邓小艳.饮食运动干预联合格列本脲对妊娠期糖尿病患者血糖控制及新生儿结局的影响[J].,2021,(10):1878-1882 |
| 饮食运动干预联合格列本脲对妊娠期糖尿病患者血糖控制及新生儿结局的影响 |
| Effects of Diet and Exercise Intervention Combined with Glibenclamide on the Blood Glucose Control and Neonatal Outcome of Gestational Diabetes Mellitus |
| 投稿时间：2020-08-26 修订日期：2020-09-22 |
| DOI：10.13241/j.cnki.pmb.2021.10.016 |
| 中文关键词: 妊娠期糖尿病 饮食 运动 格列本脲 临床疗效 |
| 英文关键词: Gestational diabetes mellitus Diet Exercise Glibenclamide Clinical efficacy |
| 基金项目:国家自然科学基金项目(81200418) |
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| 中文摘要: |
| 摘要 目的：探讨饮食运动干预联合格列本脲对妊娠期糖尿病患者血糖控制及新生儿结局的影响。方法：选取2019年1月至2019年12月于我院诊治并分娩的的妊娠期糖尿病患者100例，将其随机分为研究组和对照组，每组各50例。研究组患者接受饮食运动干预联合格列本脲治疗，对照组患者仅接受格列本脲治疗。另选取于2019年1月至2019年12月于我院进行常规健康检查并分娩的孕妇50例作为健康组，观察并对比三组患者血糖控制情况，血清CysC和Irisin水平，胰岛素抵抗相关指标，产妇和新生儿结局，分娩方式。结果：干预后，研究组空腹血糖、餐后1 h血糖、餐后2 h血糖、HbA1c、血清CysC均低于干预前，且研究组以上指标均明显低于对照组(P＜0.05)。研究组干预后血清Irisin水平高于干预前，且高于对照组(P＜0.05)。干预后，研究组HOMA-IR显著低于对照组，HOMA-?茁均显著高于对照组(P＜0.05)。研究组产后出血比例、新生儿出生体质量、新生儿低血糖和早产儿比例均低于对照组(P＜0.05)。研究组剖宫产比例少于对照组，研究组的临床总有效率显著优于对照(P＜0.05)。治疗期间，研究组和对照组均未发生不良反应。结论：饮食运动干预联合格列本脲可显著改善妊娠期糖尿病产妇和新生儿结局。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the effect of diet and exercise intervention combined with glibenclamide on the blood Glucose control, and neonatal outcome of gestational diabetes mellitus. Methods: From January 2019 to December 2019, 100 cases of gestational diabetes were selected. Randomly divided into the study group and the control group, each group has 50 cases, the study group patients receive diet and exercise intervention combined with glibenclamide treatment, the control group patients only receive glibenclamide treatment, another 50 pregnant women selected from January 2019 to December 2019 in our hospital for routine health examination and delivery as the health group, observe and compare the blood glucose control situation and serum CysC of the three groups and Irisin levels, insulin resistance related indicators, maternal and neonatal outcome indicators, mode of delivery and clinical efficacy. Results: After intervention, fasting blood glucose, postprandial 1-hour blood glucose, postprandial 2-hour blood glucose, HbA1c and serum CysC in the study group were lower than those in the control group (P<0.05). Before and after the intervention, the serum Irisin level in the study group was higher than that in the control group (P<0.05). After intervention, HOMA-IR and HOMA-β in the study group were significantly lower than those in the control group (P<0.05). The proportion of postpartum hemorrhage, birth weight, hypoglycemia and premature infants in the study group were lower than those in the control group (P<0.05). The proportion of cesarean section cases in the study group was less than that in the control group, and the total clinical effective rate in the study group was significantly better than that in the control group (P<0.05). During the treatment, no adverse reactions occurred in the study group and the control group. Conclusion: Dietary and exercise intervention combined with glibenclamide can significantly improve the maternal and neonatal outcomes of gestational diabetes mellitus. |
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