| 徐丽娟,郝改领,郑少敏,张 楠,李清华,张中馥.血清ghrelin、β-EP、BMEC在手足口病中的水平变化及诊断价值[J].,2021,(24):4774-4777 |
| 血清ghrelin、β-EP、BMEC在手足口病中的水平变化及诊断价值 |
| Analysis of the Changes of Serum Levels of Ghrelin, β-EP and BMEC in Hand-foot-mouth Disease and Their Diagnostic Value |
| 投稿时间：2021-04-23 修订日期：2021-05-17 |
| DOI：10.13241/j.cnki.pmb.2021.24.036 |
| 中文关键词: 生长激素释放肽 β-内啡肽 脑微血管内皮细胞 手足口病 诊断价值 |
| 英文关键词: Growth hormone releasing peptide β-endorphins Cerebral microvascular endothelial cells Hand, foot and mouth disease Diagnostic value |
| 基金项目:河北省医学科学研究重点课题计划项目（20180622） |
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| 中文摘要: |
| 摘要 目的：探讨血清生长激素释放肽（ghrelin）、β-内啡肽（β-EP）、脑微血管内皮细胞（BMEC）在手足口病中的水平变化及诊断价值。方法：选择2017年6月至2019年10月于我院进行治疗的150例手足口病患者进行研究，设为研究组，并选择我院120例儿童保健科查体患儿作为对照组，分析血清ghrelin、β-EP、BMEC水平变化情况及其预测价值。结果：研究组血清ghrelin水平显著低于对照组，β-EP、BMEC水平显著高于对照组，差异显著（P＜0.05）；II期患儿血清ghrelin显著高于III期、IV期患者，血清β-EP、BMEC显著低于III期、IV期患者，III期血清ghrelin显著高于IV期患者，血清β-EP 、BMEC显著低于IV期患者，差异显著（P＜0.05）；ROC结果显示，血清ghrelin预测手足口病的AUC为0.955，灵敏度为85.62%，特异度为87.45%，截断值为12.91 ng/mL；血清β-EP预测手足口病的AUC为0.801，灵敏度82.25%，特异度为83.56%，截断值为196.87 ng/L；血清BMEC预测手足口病的AUC为0.974，灵敏度为84.18%，特异度为85.97%，截断值为56.28个/mL，联合检测较单独检测灵敏度、特异度更高（P＜0.05）。结论：血清ghrelin、β-EP、BMEC与手足口病患者病情有关，有利于指导临床诊疗。 |
| 英文摘要: |
| ABSTRACT Objective: To study Analysis of the Changes of serum levels of Growth hormone releasing peptide (Ghrelin), β-endorphin (β-EP), brain microvascular endothelial cells (BMEC) in hand-foot-mouth disease and their diagnostic value. Methods: 150 HFMD patients treated in our hospital from June 2017 to October 2019 were selected as the study group, and a total of 120 children with physical examination in the Department of Children's Health Care in our hospital were selected as the control group. The changes of serum levels of Ghrelin, β-EP and BMEC and their predictive value were analyzed. Results: The serum ghrelin level in the study group was significantly lower than that in the control group, and the levels of β-EP and BMEC were significantly higher than those in the control group, with significant differences(P<0.05). The serum ghrelin of stage II patients was significantly higher than that of stage III and IV patients, the serum β-EP and BMEC of stage III patients were significantly lower than that of stage III and IV patients, the serum ghrelin of stage III patients was significantly higher than that of stage IV patients, the serum β-EP and BMEC of stage III patients were significantly lower than that of stage IV patients, the difference was significant(P<0.05). ROC results showed that the AUC of serum ghrelin in predicting HFMD was 0.955, the sensitivity was 85.62%, the specificity was 87.45%, and the cutoff value was 12.91 ng/ mL. The AUC of serum β-EP for predicting HFMD was 0.801, the sensitivity was 82.25%, the specificity was 83.56%, and the cut-off value was 196.87 ng/L. The AUC of serum BMEC in predicting HFMD was 0.974, the sensitivity was 84.18%, the specificity was 85.97%, and the cutoff value was 56.28 /mL. The combined detection had higher sensitivity and specificity than the single detection (P<0.05). Conclusion: Serum Ghrelin, β-EP and BMEC are related to the condition of patients with hand, foot and mouth disease, which is helpful to guide clinical diagnosis and treatment. |
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