| 姜宏雪,王国坤,刘 洋,徐志云.非编码RNA与胸主动脉瘤的研究进展[J].,2021,(24):4798-4800 |
| 非编码RNA与胸主动脉瘤的研究进展 |
| Progress of non-coding RNA in the Pathogenesis of Thoracic Aortic Aneurysm |
| 投稿时间：2021-02-23 修订日期：2021-03-18 |
| DOI：10.13241/j.cnki.pmb.2021.24.042 |
| 中文关键词: 非编码RNA 胸主动脉瘤 平滑肌细胞 表型转化 |
| 英文关键词: Noncoding RNAs Thoracic aortic aneurysm Smooth muscle cell Phenotypic transformation |
| 基金项目:国家自然科学基金项目（81873524） |
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| 中文摘要: |
| 摘要：非编码RNA是一类缺乏编码蛋白能力的RNA，在机体发育和疾病发生发展过程中发挥着复杂而精确的调控功能。目前认为胸主动脉瘤（Thoracic aortic aneurysm, TAA）的发病涉及遗传因素、动脉内血流动力学变化、透壁炎症反应及细胞外基质降解和重构等。研究发现胸主动脉瘤病理进展过程中，易累及主动脉中膜平滑肌细胞，从而发生平滑肌细胞的丢失以及表型转化，而这些改变受到众多非编码RNA的调节。因此本文针对非编码RNA与胸主动脉瘤发病机制的密切关联做详细阐述。 |
| 英文摘要: |
| ABSTRACT: Non-coding RNA is a variety of RNA lacking the ability to encode proteins, and it plays a complex and precise regulatory function in the organic development and process of the disease. The pathogenesis of thoracic aortic aneurysm (TAA) is very complex, involving genetic factors, arterial hemodynamic changes, transmural inflammatory response, and extracellular matrix degradation and remodeling. Studies have found that the aortic smooth muscle cells are easily involved during the progression of TAA, resulting in the loss of smooth muscle cell and phenotypic transformation, and numerous non-coding RNAs regulated these pathological changes. This review elaborates the regulation effect of non-coding RNA in the pathogenesis of thoracic aortic aneurysm. |
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