| 伍光辉,潘润德,谢新凤,蒙春夏,李德波,卢姚姚,潘江艳,兰春玲.低频重复经颅磁刺激联合艾司西酞普兰对广泛性焦虑障碍患者生活质量及事件相关电位P300的影响[J].,2022,(3):588-591 |
| 低频重复经颅磁刺激联合艾司西酞普兰对广泛性焦虑障碍患者生活质量及事件相关电位P300的影响 |
| Effects of Low Frequency Repetitive Transcranial Magnetic Stimulation Combined with Escitalopram on Quality of Life and Event-Related Potential P300 in Patients with Generalized Anxiety Disorder |
| 投稿时间：2021-07-28 修订日期：2021-08-23 |
| DOI：10.13241/j.cnki.pmb.2022.03.040 |
| 中文关键词: 低频重复经颅磁刺激 艾司西酞普兰 广泛性焦虑障碍 生活质量 事件相关电位P300 |
| 英文关键词: Low frequency repetitive transcranial magnetic stimulation Escitalopram Generalized anxiety disorder Quality of life Event related potential P300 |
| 基金项目:广西壮族自治区卫生和计划生育委员会自筹经费科研项目（Z2015720） |
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| 中文摘要: |
| 摘要 目的：观察低频重复经颅磁刺激（rTMS）联合艾司西酞普兰对广泛性焦虑障碍（GAD）患者生活质量及事件相关电位P300的影响。方法：采用随机数字表法，将2019年2月~2021年1月期间我院收治的120例GAD患者分为对照组（艾司西酞普兰治疗）和研究组（对照组的基础上接受低频rTMS治疗），各为60例。观察并对比两组疗效和不良反应，记录两组生活质量及事件相关电位P300的变化。结果：研究组的临床总有效率高于对照组（P<0.05）。研究组治疗2个月后P300潜伏期短于对照组，P300波幅长于对照组（P<0.05）。研究组治疗2个月后疼痛、生理职能、精神健康、生理功能、躯体精力、情感职能、社会功能、总体健康各维度评分高于对照组（P<0.05）。两组治疗2个月后汉密尔顿焦虑量表（HAMA）评分较治疗前下降，且研究组低于对照组（P<0.05）。两组不良反应发生率对比无统计学差异（P>0.05）。结论：低频rTMS联合艾司西酞普兰治疗GAD患者，可有效改善其焦虑症状，提高生活质量，促进认知功能恢复，具有显著的临床疗效。 |
| 英文摘要: |
| ABSTRACT Objective: To observe the effects of low frequency repetitive transcranial magnetic stimulation (rTMS) combined with escitalopram on quality of life and event-related potential P300 in patients with generalized anxiety disorder (GAD). Methods: Using random number table method, 120 patients with GAD who were admitted to our hospital from February 2019 to January 2021 were divided into control group (escitalopram treatment) and study group (low frequency rTMS treatment based on the control group), 60 cases in each group. The efficacy and adverse reactions of the two groups were observed and compared, and the changes of quality of life and event-related potential P300 were recorded. Results: The total clinical effective rate of the study group was higher than that of the control group (P<0.05). 2 months after treatment, the incubation period of P300 of the study group was shorter than that of the control group, and the amplitude of P300 was longer than that of the control group (P<0.05). The scores of pain, physical function, mental health, physical function, physical energy, emotional function, social function and overall health of the study group were higher than those of the control group at 2 months after treatment (P<0.05). 2 months after treatment, the scores of Hamilton Anxiety Scale (HAMA) in both groups were lower than those before treatment, an the study group was lower than the control group (P<0.05). There was no statistical difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion: Low frequency rTMS combined with escitalopram can effectively improve the anxiety symptoms of patients with GAD, improve the quality of life, promote the recovery of cognitive function, and which has significant clinical efficacy. |
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