文章摘要
程雅馨,杨阿丽,张旭晗,汪安友,朱薇波.血清HA、β2-MG、Flt3L联合检测对成人急性髓系白血病短期预后的评估价值[J].,2022,(9):1672-1676
血清HA、β2-MG、Flt3L联合检测对成人急性髓系白血病短期预后的评估价值
Evaluation Value of Serum HA, β2-MG and Flt3L Combined Detection for Short-Term Prognosis of Adult Acute Myeloid Leukemia
投稿时间:2021-10-10  修订日期:2021-10-31
DOI:10.13241/j.cnki.pmb.2022.09.014
中文关键词: 急性髓系白血病  透明质酸  β2微球蛋白  FMS样络氨酸激酶3配体  预后
英文关键词: Acute myeloid leukemia  Hyaluronic acid  β2 microglobulin  FMS-like tyrosine kinase 3 ligand  Prognosis
基金项目:安徽省卫生健康委科研项目(AHWJ2021b078)
作者单位E-mail
程雅馨 中国科技大学附属第一医院(安徽省立医院)血液科 安徽 合肥 230001 cheng3662022@163.com 
杨阿丽 中国科技大学附属第一医院(安徽省立医院)血液科 安徽 合肥 230001  
张旭晗 中国科技大学附属第一医院(安徽省立医院)血液科 安徽 合肥 230001  
汪安友 中国科技大学附属第一医院(安徽省立医院)血液科 安徽 合肥 230001  
朱薇波 中国科技大学附属第一医院(安徽省立医院)血液科 安徽 合肥 230001  
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中文摘要:
      摘要 目的:分析血清透明质酸(HA)、β2微球蛋白(β2-MG)、FMS样络氨酸激酶3配体(Flt3L)联合检测对成人急性髓系白血病(AML)短期预后的评估价值。方法:选取我院2018年1月~2020年12月收治的100例成人AML患者,记作研究组,另取同期健康体检者100例作为对照组,检测并对比两组血清HA、β2-MG、Flt3L水平。此外,100例成人AML患者根据1年生存预后的差异分作死亡组和存活组,对比两组血清HA、β2-MG、Flt3L水平及各项基线资料,采用多因素Logistic回归分析成人AML患者短期预后的影响因素,采用受试者工作特征(ROC)曲线分析血清HA、β2-MG、Flt3L联合检测预测成人AML患者短期预后的效能。结果:研究组患者的血清HA、β2-MG水平高于对照组受试者,而Flt3L水平低于对照组受试者(P<0.05)。死亡组患者的血清HA、β2-MG水平高于存活组患者,而Flt3L水平低于存活组患者(P<0.05)。单因素分析结果显示,死亡组年龄≥60岁、继发性AML以及未接受过诱导化疗的患者比例高于存活组(P<0.05)。进一步多因素Logistic回归分析结果显示,年龄≥60岁、继发性AML、未诱导化疗以及血清HA、β2-MG升高是成人AML患者短期预后的不利影响因素(P<0.05),而血清Flt3L水平升高是成人AML患者短期预后的有利影响因素(P<0.05)。ROC曲线分析结果显示,血清HA、β2-MG、Flt3L联合检测预测成人AML患者短期死亡的曲线下面积为0.874、灵敏度为88.91%、特异度为86.43%,均高于上述三项指标单独检测。结论:血清HA、β2-MG、Flt3L联合检测对成人AML短期预后的评估价值较高,临床上可推广应用。
英文摘要:
      ABSTRACT Objective: To analyze the evaluation value of serum hyaluronic acid (HA), β2 microglobulin (β2-MG) and FMS like tyrosine kinase 3 ligand (Flt3L) combined detection for the short-term prognosis of adult acute myeloid leukemia (AML). Methods: A total of 100 adult AML patients who were admitted to our hospital from January 2018 to December 2020 were enrolled as study group, and 100 healthy subjects in the same period were enrolled as control group. Serum HA, β2-MG and Flt3L levels were detected and compared between the two groups. In addition, 100 adult AML patients were divided into death group and survival group according to the difference of 1-year survival prognosis. Serum HA, β2-MG, Flt3L levels and baseline data of the two groups were compared. Multivariate Logistic regression was used to analyze the influencing factors of short-term prognosis of adult AML patients. Receiver operating characteristic(ROC) curve was used to analyze the efficacy of serum HA, β2-MG and Flt3L in predicting short-term prognosis in adult AML patients. Results: The serum HA and β2-MG levels in the study group patients were higher than those in the control group subjects, while the Flt3L levels was lower than that in the control group subjects(P<0.05). The HA and β2-MG levels in the death group patients were higher than those in the survival group patients, while the Flt3L level was lower than that in the survival group patients(P<0.05). Univariate analysis showed that the proportion of patients with age ≥60 years, secondary AML and no induction chemotherapy in the death group were higher than those in the survival group(P<0.05). Further multivariate Logistic regression analysis showed that age ≥60 years, secondary AML, uninduced chemotherapy and serum HA and β2-MG elevation were the adverse factors for short-term prognosis of adult AML patients(P<0.05). Increased serum Flt3L level was a favorable factor for short-term prognosis in adult AML patients(P<0.05). ROC curve analysis showed that the area under the curve of serum HA, β2-MG and Flt3L combined detection for predicting short-term death in adult AML patients were 0.874, sensitivity was 88.91%, and specificity was 86.43%, which were all higher than those of the above three indexes alone. Conclusion: The serum HA, β2-MG and Flt3L combined detection has high value in the evaluation of short-term prognosis of adult AML, and which can be widely applied in clinic.
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