文章摘要
范洋阳,袁宁霞,朱丽红,裴巧丽,张小菜,王 敏,翟 罕.血清血管细胞黏附分子-1、纤溶酶原激活物抑制物-1、血管生成素样蛋白8与妊娠期糖尿病患者妊娠结局的关系研究[J].,2022,(9):1724-1728
血清血管细胞黏附分子-1、纤溶酶原激活物抑制物-1、血管生成素样蛋白8与妊娠期糖尿病患者妊娠结局的关系研究
Relationship Study between Serum Vascular Cell Adhesion Molecule-1, Plasminogen Activator Inhibitor-1, Angiopoietin Like Protein 8 and Pregnancy Outcome in Patients with Gestational Diabetes Mellitus
投稿时间:2021-10-08  修订日期:2021-10-30
DOI:10.13241/j.cnki.pmb.2022.09.025
中文关键词: 血管细胞黏附分子-1  纤溶酶原激活物抑制物-1  血管生成素样蛋白8  妊娠期糖尿病  妊娠结局
英文关键词: Serum vascular cell adhesion molecule-1  Plasminogen activator inhibitor-1  Angiopoietin like protein 8  Gestational diabetes mellitus  Pregnancy outcome
基金项目:陕西省教育厅科学研究项目(20JK0606);陕西中医药大学第二附属医院学科创新团队项目(2020XKTD-A05)
作者单位E-mail
范洋阳 陕西中医药大学第二临床医学院 陕西 咸阳 712046 fyy199602@163.com 
袁宁霞 陕西中医药大学第二附属医院产二科 陕西 咸阳 712000  
朱丽红 陕西中医药大学第二附属医院产二科 陕西 咸阳 712000  
裴巧丽 陕西中医药大学第二附属医院产二科 陕西 咸阳 712000  
张小菜 陕西中医药大学第二附属医院产二科 陕西 咸阳 712000  
王 敏 陕西中医药大学第二附属医院产二科 陕西 咸阳 712000  
翟 罕 陕西省妇幼保健院产二科 陕西 西安 710004  
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中文摘要:
      摘要 目的:探讨血清血管细胞黏附分子-1(VCAM-1)、纤溶酶原激活物抑制物-1(PAI-1)、血管生成素样蛋白8(ANGPTL8)与妊娠期糖尿病(GDM)患者妊娠结局的关系。方法:选择2019年4月~2021年3月期间陕西中医药大学第二附属医院收治的GDM孕妇136例作为研究组。选择同时期来陕西中医药大学第二附属医院产检的健康孕妇120例作为对照组。收集研究组患者的人口学及临床资料,采用酶联免疫吸附法检测两组孕妇的血清VCAM-1、PAI-1、ANGPTL8水平,观察两组孕妇的妊娠结局情况。研究组孕妇根据妊娠结局情况分为妊娠结局不良组和妊娠结局良好组,采用单因素及多因素Logistic回归分析GDM孕妇妊娠结局不良的影响因素。结果:研究组的血清VCAM-1、PAI-1、ANGPTL8水平高于对照组(P<0.05)。研究组的妊娠结局不良总发生率高于对照组(P<0.05)。单因素分析结果显示,GDM孕妇妊娠结局不良与年龄、产前体质量指数(BMI)、糖化血红蛋白(HbAlc)、空腹血糖(FBG)、空腹胰岛素(FINS)、总胆固醇(TC)、胰岛素抵抗指数(HOMA-IR)、糖尿病家族史、分娩史、居住地、VCAM-1、PAI-1、ANGPTL8水平有关(P<0.05)。多因素Logistic回归分析显示,年龄≥35岁、产前BMI≥28 kg/m2、HbAlc水平较高、居住地为城镇、VCAM-1、PAI-1、ANGPTL8水平升高均是GDM孕妇妊娠结局不良的影响因素(P<0.05)。结论:GDM孕妇血清VCAM-1、PAI-1、ANGPTL8水平异常升高,且三者均为GDM孕妇妊娠结局的影响因素,值得临床关注。
英文摘要:
      ABSTRACT Objective: To investigate the relationship between serum vascular cell adhesion molecule-1 (VCAM-1), plasminogen activator inhibitor-1 (PAI-1), angiopoietin like protein 8 (ANGPTL8) and pregnancy outcome in patients with gestational diabetes mellitus(GDM). Methods: 136 pregnant women with GDM who were treated in The Second Affiliated Hospital of Shaanxi University of traditional Chinese Medicine from April 2019 to March 2021 were selected as the study group. 120 healthy pregnant women who came to our hospital for prenatal examination at the same time were selected as the control group. The demographic and clinical data of patients in the study group were collected, the levels of serum VCAM-1, PAI-1 and ANGPTL8 in two groups of pregnant women were detected by enzyme-linked immunosorbent assay. The pregnancy outcome of pregnant women in the two groups were observed. According to the pregnancy outcome, the pregnant women in the study group were divided into poor pregnancy outcome group and good pregnancy outcome group. Univariate and multivariate Logistic regression were used to analyze the influencing factors of adverse pregnancy outcome in GDM pregnant women. Results: The levels of serum VCAM-1, PAI-1 and ANGPTL8 in the study group were higher than those in the control group(P<0.05). The total incidence of adverse pregnancy outcome in the study group was higher than that in the control group (P<0.05). Univariate analysis showed that the poor pregnancy outcome of pregnant women with GDM were related to age, prenatal body mass index (BMI), glycosylated hemoglobin (HbAlc), fasting blood glucose (FBG), fasting insulin (FINS), total cholesterol (TC), insulin resistance index (HOMA-IR), family history of diabetes, history of childbirth, place of residence, VCAM-1, PAI-1 and ANGPTL8 levels (P<0.05). Multivariate Logistic regression analysis showed that age ≥35 years old, prenatal BMI ≥28 kg/m2, high HbAlc level, city of residence, elevated levels of VCAM-1, PAI-1 and ANGPTL8 were all influential factors of poor pregnancy outcome in pregnant women with GDM (P<0.05). Conclusion: Serum levels of VCAM-1, PAI-1 and ANGPTL8 in pregnant women with GDM are abnormally elevated, and all three are influential factors of pregnancy outcome in pregnant women with GDM, which deserved clinical attention.
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