文章摘要
曹志娟,江 东,邓 静,赵 锋,向英歌.肝硬化患者的免疫功能障碍和白蛋白相关免疫、肝纤维化进展的相关性研究[J].,2022,(9):1734-1738
肝硬化患者的免疫功能障碍和白蛋白相关免疫、肝纤维化进展的相关性研究
Study on the Correlation between Immune Dysfunction in Patients with Liver Cirrhosis and the Progress of Albumin-related Immunity and Liver Fibrosis
投稿时间:2021-09-06  修订日期:2021-09-28
DOI:10.13241/j.cnki.pmb.2022.09.027
中文关键词: 肝硬化  免疫  白蛋白  肝纤维化
英文关键词: Liver cirrhosis  Immunity  Albumin  Liver fibrosis
基金项目:宁夏回族自治区卫生健康委员会项目(2018-NW-046)
作者单位E-mail
曹志娟 宁夏医科大学附属自治区中医院肝胆脾胃病科 宁夏 银川 750021 cc984235@163.com 
江 东 宁夏医科大学附属自治区中医院肝胆脾胃病科 宁夏 银川 750021  
邓 静 宁夏医科大学附属自治区中医院肝胆脾胃病科 宁夏 银川 750021  
赵 锋 宁夏医科大学附属自治区中医院肝胆脾胃病科 宁夏 银川 750021  
向英歌 宁夏医科大学附属自治区中医院肾病科 宁夏 银川 750021  
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中文摘要:
      摘要 目的:探究肝硬化患者的免疫功能障碍和白蛋白相关免疫、肝纤维化进展的相关性。方法:选择2018年8月至2021年7月在我院检查确诊为肝硬化患者90例。将其按照肝硬化的差异区分为早期肝硬化组(45例)与晚期肝硬化组(45例)。45名年龄和性别匹配的无症状志愿者作为正常对照,并对其结果进行分析。结果:早期肝硬化组和晚期肝硬化组CD3+、CD4+、CD8+和CD20(+)均高于对照组,晚期肝硬化组高于早期肝硬化组(P<0.05);早期肝硬化组和晚期肝硬化组ALT、AST、TBIL、DBIL均高于对照组,晚期肝硬化组高于早期肝硬化组(P<0.05);早期肝硬化组和晚期肝硬化组ALB、TP、A/G、PA均低于对照组,晚期肝硬化组低于早期肝硬化组(P<0.05);早期肝硬化组和晚期肝硬化组HA、LN、PIIINP、CIV均高于对照组,晚期肝硬化组高于早期肝硬化组(P<0.05);早期肝硬化组和晚期肝硬化组的TNF-α、IL-6、TLR4和TLR9均高于对照组,晚期肝硬化组高于早期肝硬化组(P<0.05);CD3+、CD4+、CD8+、CD20+、TNF-α和IL-6与HA、LN、PNIIINP、CIV水平呈正相关,而ALB、TP、A/G和PA与HA、LN、PNIIINP、CIV水平呈负相关(P<0.05)。结论:免疫功能指标、肝功能指标浓度与四种肝纤维化标志物在联合检测可提高肝硬化诊断的可靠性和准确性,指导临床诊治,减少肝癌的发生,更好地判断疾病预后与疗效。
英文摘要:
      ABSTRACT Objective: To explore the correlation between immune dysfunction in patients with liver cirrhosis and the progress of albumin-related immunity and liver fibrosis. Methods: Choose to select 90 patients with liver cirrhosis who were diagnosed with liver cirrhosis in our hospital from August 2018 to July 2021. According to the difference of liver cirrhosis, they were divided into early cirrhosis group (45 cases) and late cirrhosis group (45 cases). Forty-five age- and gender-matched asymptomatic volunteers served as normal controls. The results were analyzed. Results: CD3+, CD4+, CD8+ and CD20+ in the early cirrhosis group and the late cirrhosis group were higher than those in the control group, the late cirrhosis group were higher than those in the early cirrhosis group(P<0.05); The ALT, AST, TBIL and DBIL were higher than those of the control group, the advanced liver cirrhosis group were higher than those of the early liver cirrhosis group(P<0.05); Early liver cirrhosis group and advanced liver cirrhosis The ALB, TP, A/G, and PA of the group were lower than those of the control group(P<0.05), and the advanced liver cirrhosis group were lower than those of the early liver cirrhosis group(P<0.05); HA, LN, PIIINP, and CIV of the early cirrhosis group and the late cirrhosis group were higher than those of the control group, and the late cirrhosis group were higher than those of the early cirrhosis group(P<0.05); TNF-α, IL-6, TLR4 and TLR9 in the early liver cirrhosis group and the advanced liver cirrhosis group were higher than those in the control group, and the the advanced liver cirrhosis group were all higher than those in the early liver cirrhosis group (P<0.05); CD3+, CD4+, CD8+, CD20+, TNF-α and IL-6 and HA, LN, PNIIINP, CIV levels are positively correlated, while ALB, TP, A/G, and PA are negatively correlated with HA, LN, PNIIINP, CIV levels(P<0.05). Conclusion: Immune function indicators, the concentration of liver function indicators and the four liver fibrosis markers were in combined detection can improve the reliability and accuracy of the diagnosis of cirrhosis, guide the clinical diagnosis and treatment, reduce the occurrence of liver cancer, and better judge the prognosis and efficacy of the disease.
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