文章摘要
王萌萌,金 钊,张秀静,侯 昌,许晓英.lncRNA-ANRIL、PON1在冠心病血清中的表达及其临床意义[J].,2022,(9):1790-1794
lncRNA-ANRIL、PON1在冠心病血清中的表达及其临床意义
Expression of lncRNA-ANRIL and PON1 in Serum of Coronary Heart Disease and Its Clinical Significance
投稿时间:2021-09-06  修订日期:2021-09-30
DOI:10.13241/j.cnki.pmb.2022.09.038
中文关键词: ANRIL  PON1  冠心病  长链非编码RNA
英文关键词: ANRIL  PON1  Coronary heart disease  Long non-coding RNA
基金项目:首都卫生发展科研专项批准项目(首发2016-3-7111)
作者单位E-mail
王萌萌 北京市昌平区中西医结合医院心内科 北京 102208 wangmm19820511@163.com 
金 钊 北京市昌平区中西医结合医院心内二科 北京 102208  
张秀静 北京中医药大学第三附属医院心内科 北京 100029  
侯 昌 北京大学人民医院心内科 北京 100000  
许晓英 北京市昌平区中西医结合医院老年病科 北京 102208  
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中文摘要:
      摘要 目的:研究非编码长链RNA ANRIL(lncRNA-ANRIL)和对氧磷酶1(PON1)在冠心病患者血清表达水平,并探讨其与冠心病患者临床意义。方法:选择2018年2月到2021年2月在我院接受治疗的冠心病患者70例作为研究组,同时随机选取同期在我院进行体检的健康志愿者70例作为对照组。比较两组患者血清lncRNA-ANRIL相对表达水平和PON1含量。采用Pearson法分析冠心病患者血清lncRNA-ANRIL相对表达水平和PON1含量与收缩压(SBP)、舒张压(DBP)、总胆固醇(TC)、甘油三脂(TG)、高密度脂蛋白(HDL-C)以及低密度脂蛋白(LDL-C)间的相关性。采用多因素Logistic回归分析冠心病发生的影响因素。结果:(1)研究组患者SBP、DBP、TG、TC和LDL-C显著高于对照组,而HDL-C显著低于对照组(P<0.05);(2)研究组血清lncRNA ANRIL Exon 1-2和Exon 17-18相对表达水平均低于对照组,研究组血清PON1含量低于对照组(P<0.05)(3)血清ANRIL Exon 1-2和Exon 17-18相对表达水平与SBP、DBP、TG、TC和LDL-C均呈负相关,与HDL-C呈正相关(P<0.05);(4)血清PON1含量与SBP、DBP、TG、TC和LDL-C均呈负相关,与HDL-C、血清ANRIL Exon 1-2和Exon 17-18相对表达水平均呈正相关(P<0.05);(5)多因素Logistic回归分析显示:TC、SBP、DBP、TG和LDL-C是冠心病发病的危险因素,HDL-C、血清ANRIL Exon 1-2和Exon 17-18相对表达水平、以及血清PON1含量是冠心病发病的保护因素。结论:冠心病患者血清lncRNA-ANRIL相对表达水平和PON1含量均降低,两者与冠心病患者血压及血脂代谢指标显著相关,且两者均为冠心病发病的保护因素。
英文摘要:
      ABSTRACT Objective: To study the expression levels of lncRNA-ANRIL and PON1 in the serum of patients with coronary heart disease, and to explore their clinical significance in patients with coronary heart disease. Methods: 70 patients with coronary heart disease who were treated in our hospital from February 2018 to February 2021 were selected as the research group, and 70 healthy volunteers who underwent physical examinations in our hospital during the same period were randomly selected as the control group. The relative expression level of lncRNA-ANRIL and the content of PON1 in the serum of the two groups were compared. Pearson's method was used to analyze the correlation between the relative expression level of serum lncRNA-ANRIL, PON1 content in patients with coronary heart disease and SBP, DBP, TC, TG, HDL-C and LDL-C. Multivariate Logistic regression was used to analyze the influencing factors of coronary heart disease. Results: (1) SBP, DBP, TG, TC and LDL-C in the study group were significantly higher than those in the control group, while HDL-C was significantly lower than that in the control group (P<0.05); (2) The relative expression levels of lncRNA ANRIL Exon 1-2 and Exon 17-18 in the study group were lower than those in the control group, and the serum PON1 content in the study group was lower than that in the control group (P<0.05); (3) The relative expression levels of ANRIL Exon 1-2 and Exon 17-18 in serum were negatively correlated with SBP, DBP, TG, TC and LDL-C, and positively correlated with HDL-C (P<0.05); (4) The serum PON1 content was negatively correlated with SBP, DBP, TG, TC and LDL-C, and positively correlated with HDL-C, ANRIL Exon 1-2 and Exon 17-18 in serum (P<0.05). (5) Multivariate Logistic regression analysis showed that TC, SBP, DBP, TG and LDL-C were risk factors for CHD, while HDL-C, serum ANRIL Exon 1-2 and Exon 17-18 relative expression levels, and serum PON1 content were protective factors for CHD. Conclusion: Both the relative expression level of lncrna-AnRIL and the content of PON1 in serum were decreased in patients with CORONARY heart disease, and both were significantly correlated with blood pressure and lipid metabolism indexes in patients with coronary heart disease, and both were protective factors for the onset of CORONARY heart disease.
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