文章摘要
黄 芯,莫训群,邓 熹,沈永龙,谭 媛.早产产妇血清和胎盘IL-17、IL-21及IL-22表达水平与新生儿感染发生的相关性研究[J].,2024,(3):587-590
早产产妇血清和胎盘IL-17、IL-21及IL-22表达水平与新生儿感染发生的相关性研究
Correlation between the Expression Levels of IL-17, IL-21 and IL-22 in Serum and Placenta of Preterm Mothers and Neonatal Infection
投稿时间:2023-07-05  修订日期:2023-07-27
DOI:10.13241/j.cnki.pmb.2024.03.036
中文关键词: 早产  血清  胎盘  IL-17  IL-21  IL-22  新生儿感染
英文关键词: Premature birth  Serum  Placenta  IL-17  IL-21  IL-22  Neonatal infection
基金项目:广西壮族自治区卫生健康委员会项目/广西医疗卫生重点培育学科建设项目(Z20201222)
作者单位E-mail
黄 芯 桂林医学院附属医院产科 广西 桂林 541001 huangxin26638941@163.com 
莫训群 桂林医学院附属医院产科 广西 桂林 541001  
邓 熹 桂林医学院附属医院产科 广西 桂林 541001  
沈永龙 桂林医学院附属医院产科 广西 桂林 541001  
谭 媛 桂林医学院附属医院新生儿科 广西 桂林 541001  
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中文摘要:
      摘要 目的:分析早产产妇血清和胎盘IL-17、IL-21及IL-22表达水平与新生儿感染发生的相关性。方法:选择2020年7月至2021年12月在我院分娩的120例早产产妇作为观察组,另选同期的120例足月分娩产妇作为对照组。检测两组产妇血清和胎盘IL-17、IL-21及IL-22表达水平,根据观察组产妇分娩的新生儿是否发生感染,分为感染组和非感染组,比较两组母体血清和胎盘IL-17、IL-21及IL-22表达水平,使用多因素Logistic回归分析和受试者工作特征曲线(ROC)分析早产产妇血清和胎盘IL-17、IL-21及IL-22与新生儿感染的关系。结果:观察组血清和胎盘IL-17、IL-21及IL-22表达水平均高于对照组(P<0.05);感染组母体血清和胎盘IL-17、IL-21及IL-22表达水平均高于非感染组(P<0.05);经多因素Logistic回归分析,早产产妇血清和胎盘IL-17、IL-21及IL-22均是新生儿感染发生的独立预测因素(P<0.05);经Pearson相关性分析,早产产妇血清IL-17与胎盘IL-17 mRNA、血清IL-21与胎盘IL-21 mRNA、血清IL-22与胎盘IL-22 mRNA均呈正相关(P<0.05);经ROC曲线分析,早产产妇血清IL-17、IL-21联合IL-22预测新生儿感染发生的AUC为0.910。结论:早产产妇血清和胎盘IL-17、IL-21及IL-22表达水平升高均与新生儿感染发生密切相关,其中血清IL-17、IL-21联合IL-22预测新生儿感染的效能较高,值得进一步研究应用。
英文摘要:
      ABSTRACT Objective: To analyze the correlation between the expression levels of IL-17, IL-21 and IL-22 in serum and placenta of preterm pregnant women and neonatal infection. Methods: 120 preterm parturients who delivered in our hospital from July 2020 to December 2021 were selected as the observation group, and 120 full-term parturients in the same period were selected as the control group. The expression levels of IL-17, IL-21 and IL-22 in serum and placenta of mothers in the two groups were detected. According to whether newborns delivered by mothers in the observation group were infected or not, they were divided into infected group and non-infected group. The expression levels of IL-17, IL-21 and IL-22 in serum and placenta of mothers in the two groups were compared. Multivariate Logistic regression analysis and receiver operating characteristic curve (ROC) were used to analyze the relationship between serum and placental IL-17, IL-21 and IL-22 and neonatal infection. Results: The expression levels of IL-17, IL-21 and IL-22 in serum and placenta of observation group were higher than those of control group(P<0.05). The expression levels of IL-17, IL-21 and IL-22 in serum and placenta of infected group were higher than those of non-infected group(P<0.05). Multivariate Logistic regression analysis showed that serum and placental IL-17, IL-21 and IL-22 were independent predictors of neonatal infection (P<0.05). According to Pearson correlation analysis, there were positive correlations between serum IL-17 and placental IL-17 mRNA, serum IL-21 and placental IL-21 mRNA, and serum IL-22 and placental IL-22 mRNA in preterm parturients(P<0.05). According to ROC curve analysis, the AUC of serum IL-17 and IL-21 combined with IL-22 for predicting neonatal infection was 0.910. Conclusion: The elevated levels of IL-17, IL-21 and IL-22 in serum and placenta of preterm parturients are closely related to the occurrence of neonatal infection, and the efficacy of serum IL-17, IL-21 and IL-22 combined with IL-22 in predicting neonatal infection is higher, which is worthy of further study and application.
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