| 张艳阳,蔡建叶,邱玉坤,杨 娟,唐玉彬.振幅整合脑电图评分联合ox-LDL/HDL比值、hs-CRP/Alb比值、FAR对急性脑梗死患者预后的预测价值[J].,2024,(12):2391-2395 |
| 振幅整合脑电图评分联合ox-LDL/HDL比值、hs-CRP/Alb比值、FAR对急性脑梗死患者预后的预测价值 |
| Predictive Value of Amplitude Integrated Electroencephalogram Score Combine with Ox-LDL/HDL Ratio, Hs-CRP/Alb Ratio and FAR on the Prognosis of Patients with Acute Cerebral Infarction |
| 投稿时间：2024-01-08 修订日期：2024-01-31 |
| DOI：10.13241/j.cnki.pmb.2024.12.038 |
| 中文关键词: 振幅整合脑电图 ox-LDL/HDL比值 hs-CRP/Alb比值 FAR 急性脑梗死 预后 |
| 英文关键词: Amplitude integrated electroencephalography ox-LDL/HDL hs-CRP/Alb FAR Acute cerebral infarction Prognosis |
| 基金项目:甘肃省科技计划项目（20YF3FH-237）；兰州市科技计划项目（2021-1-103） |
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| 中文摘要: |
| 摘要 目的：探讨振幅整合脑电图（aEEG）评分联合氧化低密度脂蛋白/高密度脂蛋白（ox-LDL/HDL）比值、高敏C反应蛋白/白蛋白（hs-CRP/Alb）比值、纤维蛋白原/白蛋白比值（FAR）对急性脑梗死（ACI）患者预后的预测价值。方法：选择2021年1月至2022年l2月我院收治的242例ACI患者，均行aEEG检查获得aEEG评分，检测血清ox-LDL/HDL比值、hs-CRP/Alb比值、FAR。出院3个月后采用改良Rankin量表（mRS）评估患者预后。收集ACI患者的临床资料，多因素Logistic回归分析ACI患者预后不良的影响因素。受试者工作用特征（ROC）曲线分析aEEG评分、血清ox-LDL/HDL比值、hs-CRP/Alb比值、FAR预测ACI患者预后的效能。结果：预后不良组aEEG评分、血清ox-LDL/HDL比值、hs-CRP/Alb比值、FAR均高于预后良好组（P＜0.05）。多发脑梗死病灶、高NHISS评分、高aEEG评分、高ox-LDL/HDL比值、高hs-CRP/Alb比值和高FAR是ACI患者预后不良的危险因素（P＜0.05）。aEEG评分、血清ox-LDL/HDL比值、hs-CRP/Alb比值、FAR预测ACI患者预后的曲线下面积分别为0.793、0.759、0.777、0.821，联合预测的曲线下面积为0.915，高于单独指标预测。结论：ACI预后不良患者aEEG评分、ox-LDL/HDL比值、hs-CRP/Alb比值、FAR均升高，上述指标联合应用预测ACI患者预后不良具有较高的价值。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the predictive value of amplitude integrated electroencephalogram (aEEG) score combine with oxidized low-density lipoprotein/high-density lipoprotein (ox-LDL/HDL) ratio, high-sensitivity C-reactive protein/albumin (hs-CRP/Alb) ratio and fibrinogen/albumin ratio (FAR) on the prognosis of patients with acute cerebral infarction (ACI). Methods: 242 ACI patients admitted to our hospital from January 2021 to December 2022 were selected, all patients underwent aEEG examination to obtain aEEG score, and serum ox-LDL/HDL ratio, hs-CRP/Alb ratio and FAR were detected. The modified Rankin scale (mRS) was used to evaluate the prognosis of patients 3 months after discharge. The clinical data of ACI patients were collected, and the influencing factors of poor prognosis of ACI patients were analyzed by multivariate Logistic regression. The efficacy of aEEG score, serum ox-LDL/HDL ratio, hs-CRP/Alb ratio and FAR in predicting the prognosis of ACI patients were analyzed by receiver operating characteristic (ROC) curve. Results: The aEEG score, serum ox-LDL/HDL ratio, hs-CRP/Alb ratio and FAR in poor prognosis group were higher than those in good prognosis group(P<0.05). Multiple cerebral infarction lesions, high NHISS score, high aEEG score, high ox-LDL/HDL ratio, high hs-CRP/Alb ratio and high FAR were risk factors for poor prognosis in ACI patients(P<0.05). The area under the curve of aEEG score, serum ox-LDL/HDL ratio, hs-CRP/Alb ratio and FAR in predicting the prognosis of ACI patients were 0.793, 0.759, 0.777 and 0.821 respectively. The area under the curve of combined prediction was 0.915, which was higher than that of single index prediction. Conclusion: The aEEG score, ox-LDL/HDL ratio, hs-CRP/Alb ratio and FAR are increase in patients with poor prognosis of ACI. The combined application of the above indicators has a high value in predicting the poor prognosis of ACI patients. |
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