| 顾胤烨,陈建栋,孔宪诚,陈 晨,詹有芳,周 伟,邬晓丽,石 磊.分化型甲状腺癌术后131I治疗患者血清Tg、MIP-1α、GPX3与预后的关系[J].,2024,(19):3641-3644 |
| 分化型甲状腺癌术后131I治疗患者血清Tg、MIP-1α、GPX3与预后的关系 |
| Relationship between Serum Tg, MIP-1α, GPX3 and Prognosis in Patients Treated with 131I after Differentiated Thyroid Cancer Surgery |
| 投稿时间：2024-04-18 修订日期：2024-05-12 |
| DOI：10.13241/j.cnki.pmb.2024.19.008 |
| 中文关键词: 分化型甲状腺癌 Tg MIP-1α GPX3 碘-131 预后 |
| 英文关键词: Differentiated thyroid cancer Tg MIP-1α GPX3 131iodine Prognosis |
| 基金项目:上海市教育委员会自然科学类科研基金资助项目（18TS080）；上海中医药大学预算内项目（2022YJ-20） |
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| 中文摘要: |
| 摘要 目的：探讨分化型甲状腺癌（DTC）术后碘-131（131I）治疗患者血清甲状腺球蛋白（Tg）、巨噬细胞炎性蛋白-1α（MIP-1α）、谷胱甘肽过氧化物酶3（GPX3）与预后的关系。方法：接受手术联合131I治疗的DTC患者180例作为DTC组，根据131I治疗后2年是否复发/转移将DTC患者分为预后不良组和预后良好组。检测血清Tg、MIP-1α、GPX3水平。通过Logistic回归分析DTC术后131I治疗患者预后的影响因素。结果：与预后良好组比较，预后不良组血清Tg、MIP-1α水平升高，GPX3水平降低（P＜0.05）。DTC术后131I治疗患者预后不良的独立危险因素为TNM分期III-IV期和Tg、MIP-1α升高，而GPX3升高为独立保护因素（P＜0.05）。结论：DTC术后131I治疗患者血清Tg、MIP-1α水平升高和GPX3水平降低与预后不良密切相关。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between serum thyroglobulin (Tg), macrophage inflammatory protein-1α (MIP-1α), glutathione peroxidase 3 (GPX3) and the prognosis in patients treated with iodine-131 (131I) after differentiated thyroid cancer (DTC) surgery. Methods: 180 DTC patients who received surgery combined with 131I treatment were selected as the DTC group, and patients were divided into poor prognosis group and good prognosis group according to whether they had recurrence/metastasis at 2 years after 131I treatment. Detected serum Tg, MIP-1α and GPX3 levels. The factors affecting the prognosis of patients treated with 131I after DTC surgery were analyzed by Logistic regression. Results: Compared with the good prognosis group, serum Tg and MIP-1α levels were increased and GPX3 levels were decreased in the poor prognosis group(P＜0.05). The independent risk factors for poor prognosis in patients treated with 131I after DTC surgery were TNM stage III-IV and elevated Tg, and MIP-1α, and elevated GPX3 was an independent protective factor (P＜0.05). Conclusion: Elevated serum Tg, MIP-1α levels and reduced GPX3 levels are closely associated with poor prognosis in patients treated with 131I after DTC surgery. |
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