| 王衍颜,张 军,毛 沛,尹立辉,陈 晶.肺鳞状细胞癌组织PCBP1、GPSM2表达与EMT、临床病理特征和预后的关系[J].,2024,(19):3654-3656 |
| 肺鳞状细胞癌组织PCBP1、GPSM2表达与EMT、临床病理特征和预后的关系 |
| Relationship between Expression of PCBP1 and GPSM2 in Lung Squamous Cell Carcinoma Tissue and EMT, Clinical Pathological Features, and Prognosis |
| 投稿时间：2024-03-25 修订日期：2024-04-21 |
| DOI：10.13241/j.cnki.pmb.2024.19.012 |
| 中文关键词: 肺鳞状细胞癌 多聚胞嘧啶结合蛋白-1 G蛋白信号调节蛋白2 上皮-间质转化 临床病理特征 预后 |
| 英文关键词: Lung squamous cell carcinoma Poly C binding protein-1 G-protein signaling modulator 2 Epithelial-mesenchymal transition Clinical pathological features Prognosis |
| 基金项目:山东省自然科学基金项目（2019052） |
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| 中文摘要: |
| 摘要 目的：探讨肺鳞状细胞癌组织多聚胞嘧啶结合蛋白-1（PCBP1）、G蛋白信号调节蛋白2（GPSM2）表达与上皮-间质转化（EMT）、临床病理特征和预后的关系。方法：选取2018年1月到2020年6月我院行手术切除的80例肺鳞状细胞癌患者作为研究对象，分析肺鳞状细胞癌患者癌组织PCBP1、GPSM2与EMT标志物、临床病理特征和预后的关系。结果：癌组织PCBP1、GPSM2、E-cadherin的阳性表达率与癌旁组织比较均下降，vimentin阳性表达率上升（P<0.05）。PCBP1、GPSM2阳性表达与vimentin呈负相关，与E-cadherin呈正相关（P<0.05）。PCBP1、GPSM2阳性表达率与低分化、TNM分期ⅢA期、淋巴结转移有关（P<0.05）。PCBP1、GPSM2阳性表达患者的生存率高于PCBP1、GPSM2阴性表达患者（P<0.05）。结论：肺鳞状细胞癌患者癌组织中PCBP1、GPSM2低表达与低分化、TNM分期ⅢA期、淋巴结转移有关，可促进肺鳞状细胞癌EMT，并导致不良预后。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the relationship between the expression of poly C binding protein-1 (PCBP1) and G-protein signaling modulator 2 (GPSM2) in lung squamous cell carcinoma tissue and epithelial mesenchymal transition (EMT), clinical pathological features, and prognosis. Methods: 80 patients with lung squamous cell carcinoma who underwent surgical resection in our hospital from January 2018 to June 2020 were selected as the study objects,.analysis of the relationship between cancer tissue PCBP1, GPSM2, EMT markers, clinical pathological characteristics and prognosis in patients with lung squamous cell carcinoma tissue. Results: The positive expression rates of PCBP1, GPSM2 and E-cadherin in cancer tissues decreased compared to paracancer tissues, while the positive expression rate of vimentin was increased(P<0.05). The positive expression of PCBP and GPSM2 were negatively correlated with vimentin, and positively correlated with E-cadherin(P<0.05). The positive expression rates of PCBP1 and GPSM2 were correlated with low differentiation, TNM stage IIIA and lymph node metastasis(P<0.05). The survival rate of patients with positive expression of PCBP1 and GPSM2 is higher than that of patients with negative expression(P<0.05). Conclusion: The positive expression rates of PCBP1 and GPSM2 in cancer tissues of patients with lung squamous cell carcinoma decrease. The low expression of PCBP1 and GPSM2 is related to low differentiation, TNM stage IIIA, and lymph node metastasis, which can promote EMT of lung squamous cell carcinoma and lead to poor prognosis. |
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