| 李 萌,潘修成,彭 乐,张 硕,毛传春.耐多药肺结核患者血清OPN、HMGB1与T细胞亚群和化学治疗疗效的关系分析[J].,2024,(19):3758-3760 |
| 耐多药肺结核患者血清OPN、HMGB1与T细胞亚群和化学治疗疗效的关系分析 |
| Analysis of the Relationship between Serum OPN, HMGB1 and T cell Subsets and Chemotherapy Efficacy in Patients with Multidrug-Resistant Pulmonary Tuberculosis |
| 投稿时间：2024-03-07 修订日期：2024-03-30 |
| DOI：10.13241/j.cnki.pmb.2024.19.041 |
| 中文关键词: 耐多药肺结核 T细胞亚群 化学治疗 疗效 骨桥蛋白 高迁移率族蛋白B1 |
| 英文关键词: Multidrug-resistant pulmonary tuberculosis T cell subsets Chemotherapy Efficacy Osteopontin High mobility group protein B1 |
| 基金项目:江苏省高等学校自然科学研究面上项目（20KJD180528） |
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| 中文摘要: |
| 摘要 目的：探讨耐多药肺结核（MDR-TB）患者血清骨桥蛋白（OPN）、高迁移率族蛋白B1（HMGB1）与T细胞亚群和化学治疗疗效的关系。方法：选择2018年3月至2021年9月徐州市传染病医院收治的147例MDR-TB患者（MDR-TB组），另选择同期徐州市传染病医院收治的109例非MDR-TB患者（对照组）。Pearson相关性分析MDR-TB组血清OPN、HMGB1与外周血T细胞亚群的相关性。多因素Logistic回归分析MDR-TB治疗未成功的因素。结果：MDR-TB组血清OPN、HMGB1与外周血CD8+计数呈正相关（P＜0.05），与外周血CD3+计数、CD4+计数、CD4+/CD8+比值呈负相关（P＜0.05）。未成功组血清OPN、HMGB1水平高于成功组（P＜0.05）。多因素Logistic回归分析结果显示空洞、高OPN、高HMGB1是MDR-TB治疗未成功的危险因素（P＜0.05）。结论：MDR-TB患者血清OPN、HMGB1水平显著升高，且与T细胞亚群异常以及化学治疗未成功有关。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between serum osteopontin (OPN), high mobility group protein B1 (HMGB1) and T cell subsets and chemotherapy efficacy in patients with multidrug-resistant pulmonary tuberculosis (MDR-TB). Methods: 147 MDR-TB patients (MDR-TB group) admitted to Xuzhou Infectious Disease Hospital from March 2018 to September 2021 were selected, and 109 non-MDR-TB patients (control group) admitted to Xuzhou Infectious Disease Hospital during the same period were selected. The correlation between serum OPN, HMGB1 and peripheral blood T cell subsets in MDR-TB group was analyzed by Pearson correlation analysis. The factors of unsuccessful MDR-TB treatment were analyzed by multivariate Logistic regression analysis. Results: Serum OPN and HMGB1 in MDR-TB group were positively correlated with peripheral blood CD8+ count (P<0.05), and negatively correlated with peripheral blood CD3+ count, CD4+ count and CD4+/CD8+ ratio (P<0.05). Multivariate Logistic regression analysis showed that cavity, high OPN and high HMGB1 were risk factors for unsuccessful MDR-TB treatment(P<0.05). Conclusion: The levels of serum OPN and HMGB1 in MDR-TB patients are significantly increase, which are relate to the abnormality of T cell subsets and the failure of chemotherapy. |
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