| 李 巧,陈基黎,王 雷,张照委,孙 梅.糖尿病性黄斑水肿患者血清VEGF、MCP-1、Hcy的表达及其临床意义分析[J].,2024,(19):3778-3780 |
| 糖尿病性黄斑水肿患者血清VEGF、MCP-1、Hcy的表达及其临床意义分析 |
| Expression and Clinical Significance of Serum VEGF, MCP-1 and Hcy in Patients with Diabetic Macular Edema |
| 投稿时间：2024-05-16 修订日期：2024-06-07 |
| DOI：10.13241/j.cnki.pmb.2024.19.047 |
| 中文关键词: 糖尿病性黄斑水肿 血管内皮生长因子 单核细胞趋化因子蛋白-1 同型半胱氨酸 |
| 英文关键词: Diabetic macular edema Vascular endothelial growth factor Monocyte chemoattractant protein-1 Homocysteine |
| 基金项目:江苏省高等学校自然科学研究项目（20KJA160426） |
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| 中文摘要: |
| 摘要 目的：探讨糖尿病性黄斑水肿（DME）患者血清血管内皮生长因子（VEGF）、单核细胞趋化因子蛋白-1（MCP-1）、同型半胱氨酸（Hcy）的表达及其临床意义。方法：选取2020年3月-2022年3月在我院治疗的115例DME患者纳入DME组，收集同期在我院门诊治疗的无DME的单纯2型糖尿病（T2DM）患者80例纳入对照组。对比两组的血清VEGF、MCP-1、Hcy水平。收集两组临床资料，采用单因素和多因素Logistic回归分析DME发病的影响因素。结果：DME组的血清VEGF、MCP-1、Hcy水平高于对照组（P<0.05）。DME发病与高密度脂蛋白（HDL-C）、性别、甘油三酯（TG）、低密度脂蛋白（LDL-C）、空腹血糖、体质量指数（BMI）、尿素氮、年龄、肌酐无关（P>0.05），而与糖尿病病程、糖化血红蛋白、总胆固醇（TC）有关（P<0.05）。多因素Logistic回归分析结果显示，糖尿病病程偏长、TC偏高、血清VEGF偏高、MCP-1偏高、Hcy偏高是DME发病的危险因素（P<0.05）。结论：DME患者血清VEGF、MCP-1、Hcy升高，血清VEGF、MCP-1、Hcy是DME发生的影响因素。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the expression and clinical significance of serum vascular endothelial growth factor (VEGF),monocyte chemoattractant protein-1 (MCP-1) and homocysteine (Hcy) in patients with diabetic macular edema (DME). Methods: 115 DME patients who were treated in our hospital from March 2020 to March 2022 were selected as DME group, and 80 patients with type 2 diabetes mellitus (T2DM) without DME who were treated in our hospital during the same period were collected as control group .The levels of serum Hcy, VEGF and MCP-1 in control group and DME group were compared. Clinical data from both groups were collected, and univariate and multivariate Logistic regression was used to analyze the factors affecting the onset of DME. Results: The levels of serum Hcy, VEGF and MCP-1 in DME group were higher than those in control group (P<0.05). The incidence of DME was not related to high density lipoprotein (HDL-C), gender, triglyceride (TG), low density lipoprotein (LDL-C), fasting blood glucose, body mass index (BMI), urea nitrogen, age and creatinine(P>0.05), but was related to the course of diabetes mellitus, glycosylated hemoglobin and total cholesterol (TC) (P<0.05). Multivariate Logistic regression analysis showed that, longer duration of diabetes mellitus, higher TC, higher serum Hcy, higher VEGF and higher MCP-1 were risk factors for DME(P<0.05). Conclusion: The levels of serum Hcy, VEGF and MCP-1 in DME patients are increase, and serum Hcy, VEGF and MCP-1 are the influencing factors of DME. |
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