| 彭 颖,秦 宝,黄 媛,甘祥海,李孟秦.多巴酚丁胺联合氢溴酸山莨菪碱对脓毒性休克患者内皮功能、免疫功能的影响[J].,2024,(19):3788-3791 |
| 多巴酚丁胺联合氢溴酸山莨菪碱对脓毒性休克患者内皮功能、免疫功能的影响 |
| Effects of Dobutamine Combined with Anisodamine Hydrobromide on Endothelial Function and Immune Function in Patients with Septic Shock |
| 投稿时间：2024-05-11 修订日期：2024-06-04 |
| DOI：10.13241/j.cnki.pmb.2024.19.050 |
| 中文关键词: 多巴酚丁胺 氢溴酸山莨菪碱 脓毒性休克 内皮功能 免疫功能 |
| 英文关键词: Dobutamine Anisodamine hydrobromide Septic shock Endothelial function Immune function |
| 基金项目:四川省南充市市校合作科研专项资金项目（19SXHZ0056） |
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| 中文摘要: |
| 摘要 目的：研究分析多巴酚丁胺联合氢溴酸山莨菪碱对脓毒性休克患者内皮功能、免疫功能的影响。方法：选我院100例2023年1月～2024年1月收治的脓毒性休克患者，按随机数字表法分为对照组、观察组，各50例。对照组给予多巴酚丁胺+生理盐水治疗，观察组给予多巴酚丁胺联合氢溴酸山莨菪碱治疗。结果：治疗后，与观察组相比，对照组TNF-α、CRP、IL-6、PCT、VO2、O2ER、E-SLT、sTM、ET-1、Ang-2、CD8+水平均上升，而ScvO2、DO2、CD4+、CD3+、CD4+/CD8+均表现下降，有统计学差异（P＜0.05）；且对照组住院时间、下床活动时间、休克持续时间均显著高于观察组，而临床总有效率低于观察组（P＜0.05）。结论：多巴酚丁胺联合氢溴酸山莨菪碱可改善脓毒性休克患者内皮功能，清除炎症介质，提高免疫功能，降低并发症发生率，有临床应用价值。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effects of dobutamine combined with anisodamine hydrobromide on endothelial function and immune function in patients with septic shock. Methods: A total of 100 patients with septic shock admitted from January 2023 to January 2024 were randomly divided into control group and observation group, with 50 cases each. The control group was given dobutamine and normal saline, and the observation group was given dobutamine and anisodaminehydrobromide. Results: After treatment, compared with the observation group, the levels of TNF-α, CRP, IL-6, PCT, VO2, O2ER, E-SLT, sTM, ET-1, Ang-2 and CD8+ in the control group were all increased, while the levels of ScvO2, DO2, CD4+, CD3+ and CD4+/CD8+ were decreased. There was statistical difference (P<0.05). In addition, the length of hospital stay, time of getting out of bed and duration of shock in control group were significantly higher than those in observation group, while the total clinical effective rate was lower than that in observation group (P<0.05). Statistical difference between the two groups (P>0.05). Conclusion: Dobutamine combined with anisodamine hydrobromide can improve the endothelial function, clear the inflammatory mediators, improve immune function, and reduce the incidence of complications on septic shock patients, which has clinical application value. |
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