| 王 蕾,李斐然,肖建香,戴艳环,吴学文.益肾逐瘀方对血液透析合并骨质疏松患者营养状况及生活质量的临床观察[J].,2025,(18):2925-2932 |
| 益肾逐瘀方对血液透析合并骨质疏松患者营养状况及生活质量的临床观察 |
| Clinical Observation of the Effect of Kidney Tonifying and Blood Stasis Removing Formula on Nutritional Status and Quality of Life in Patients with Osteoporosis Combined with Hemodialysis |
| 投稿时间：2025-05-12 |
| DOI：10.13241/j.cnki.pmb.2025.18.007 |
| 中文关键词: 益肾逐瘀方 血液透析 肝肾阴虚 营养状况 生活质量 |
| 英文关键词: Kidney tonifying and blood stasis removing formula Hemodialysis Liver and kidney yin deficiency Nutritional status Quality of life |
| 基金项目:江苏省中医药学会振兴发展项目（ZXFZ2024053）；徐州市科技局重点研发计划项目（KC23347） |
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| 中文摘要: |
| 摘要 目的：探讨益肾逐瘀方对血液透析合并骨质疏松患者营养状况及生活质量的作用。方法：选取2024年1月至2025年1月邳州市中医院血液透析中心肝肾阴虚、瘀血阻滞型60例血液透析合并骨质疏松患者。随机将60例患者分为两组，各30例。对照组予一般治疗加帕立骨化醇治疗，治疗组在对照组的基础上联合应用益肾逐瘀方，疗程为12周。比较治疗前后中医证候积分、改良定量主观评估表（MQSGA）、肾脏与生活治疗（KDQOLTM-36）量表、血脂、营养指标的变化。结果：治疗后两组中医证候积分均明显下降（P<0.05），治疗组下降更明显（P<0.05）；治疗组KDQOLTM-36评分升高（P<0.05），对照组升高不明显（P>0.05），治疗组明显优于对照组（P<0.05）；两组MQSGA评分均下降（P<0.05），虽二者差异无统计学意义（P>0.05），但治疗组评分下降明显；治疗组TC、TG、LDL、TG/HDL均明显下降，HDL明显升高（P<0.05），对照组的TC及HDL较前无明显变化（P＞0.05），TG、LDL及TG/HDL较前明显升高（P<0.05）。治疗组明显优于对照组（P<0.05）。治疗组TRF、Hb及ALB水平升高（P<0.05）；对照组升高不明显（P>0.05）。治疗组优于对照组（P<0.05）。治疗组总有效率为90%，明显优于对照组（总有效率为23.3%）（P<0.05）。结论：益肾逐瘀方可改善肝肾阴虚、瘀血阻滞型血液透析合并骨质疏松患者营养状况及生活质量。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the effect of kidney-strengthening and blood stasis-eliminating formula on nutritional status and quality of life in patients with osteoporosis combined with hemodialysis. Methods: From January 2024 to January 2025, 60 patients with liver and kidney yin deficiency and blood stasis obstruction were selected from the Pizhou City Traditional Chinese Medicine Hospital's Hemodialysis Center. 60 patients were randomly divided into two groups, 30 in each group. The matched group received general treatment plus paricalcitol, while the treatment group received the same treatment plus Yishen Zhuyu Fang (a traditional Chinese medicine formula for kidney and blood stasis). The treatment course lasted 12 weeks. Changes in TCM syndrome scores, the Modified Subjective Global Assessment (MQSGA), the Kidney and Life Quality (KDQOLTM-36) scale, lipid levels, and nutritional indicators were compared before and after treatment. Results: After treatment, the TCM syndrome scores in both groups decreased (P<0.05), with a more pronounced decrease in the treatment group (P<0.05). The KDQOLTM-36 score in the treatment group increased (P<0.05), while the increase was not significant in the matched group (P>0.05), indicating that the treatment group performed better than the matched group (P<0.05). Both groups experienced a decrease in the MQSGA score (P<0.05), although the difference was not statistically significant (P>0.05), the treatment group showed a more noticeable decline. The TC, TG, LDL, and TG/HDL levels in the treatment group all decreased significantly, while HDL levels increased (P<0.05). In contrast, the TC and HDL levels in the matched group did not change (P>0.05), while the TG, LDL, and TG/HDL levels increased (P<0.05). The treatment group performed significantly better than the matched group (P<0.05). The TRF, Hb, and ALB levels in the treatment group increased (P<0.05), while the increase was not significant in the matched group (P>0.05). The total effective rate of the treatment group was 90%, higher than the matched group (23.3%) (P<0.05). Conclusion: The formula of tonifying the kidney and removing stasis can improve the nutritional status and quality of life of patients with liver and kidney yin deficiency and blood stasis obstruction in hemodialysis combined with osteoporosis. |
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