Objective: To study the clinical effect comparison of of three screening methods for cervical cancer and the cognitive status of positive screening patients. Methods: A total of 287 patients with indications for colposcopy and completed colposcopy and cervical biopsy from March 2018 to December 2019 were selected as the study subjects. Cervical thinprep cytologic test (TCT) examination, human papillomavirus-deoxyribonucleic acid (HPV-DNA) examination and quantitative cell DNA examination were performed for all subjects before colposcopy. Taking the pathological examination results after biopsy as the gold standard, the sensitivity, specificity and accuracy of the above three cervical cancer screening methods were. In addition, a self-designed questionnaire was used to determine the cognitive status of positive cervical cancer screening patients. Results: Using the pathological results as the gold standard, cervical intraepithelial neoplasia 2 (CIN2) and above were positive, the sensitivity, specificity and accuracy of TCT examination were 68.63% (35/51), 78.81% (186/236) and 77.00% (221/287), respectively. The sensitivity, specificity and accuracy of HPV-DNA examination in cervical precancerous lesions were 94.12% (48/51), 59.32% (140/236) and 65.51% (188/287), respectively. The sensitivity, specificity and accuracy of quantitative detection of cervical precancerous lesions by quantitative cell DNA examination were 72.55 (37/51), 86.86% (205/236) and 84.32% (242/287), respectively. The sensitivity of HPV-DNA examination was higher than that of TCT examination and quantitative cell DNA examination (P<0.05), and the specificity and accuracy of quantitative cell DNA examination were higher than that of TCT examination and HPV-DNA examination (P<0.05). The number of people who understanding cervical cancer screening accounted for 92.16%, the number of people who understanding the importance of regular cervical cancer screening accounted for 17.65%, the number of people who understanding cervical cancer screening methods accounted for 9.80%, the number of people who understanding HPV related knowledge accounted for 0.00%, and the number of people who understanding cervical cancer screening could detect lesions early accounted for 15.69%. Conclusion: The application of HPV-DNA examination in cervical cancer screening has a high sensitivity, while the quantitative cell DNA examination has a high specificity and accuracy, and the cognitive status of screening positive patients needs to be improved. |