Objective To observe the clinical efficacy of Shenxian Shengmai oral liquid combined with trimetazidine in the treatment of bradyarrhythmia (BA) for 4 weeks after treatment and its effect on the levels of cyclic adenosine phosphate (cAMP)/protein kinase A (PKA) signaling pathway related proteins in peripheral blood mononuclear cells. Methods 126 BA patients in our hospital from August 2017 to August 2020 were randomly divided into two groups, the control group and the observation group, 63 cases in each group. The control group was treated with trimetazidine, and the observation group was treated with Shenxian Shengmai oral liquid combined with trimetazidine. The 24-hour dynamic electrocardiogram indexes (slowest heart rate, resting heart rate, 24h average heart rate), cardiac function indexes [left ventricular ejection fraction (LVEF), cardiac output (CO), cardiac index (CI)], curative effect, cAMP / PKA signal pathway related protein (cAMP protein, PKA protein) levels and adverse reactions of the two groups were observed and compared. Results The total effective rate of the observation group was 90.48% (57 / 63), which was higher than 71.43% (45 / 63) of the control group, the difference was statistically significant (P<0.05). 4 weeks after treatment, compared to the control group, the resting heart rate, 24h average heart rate and slowest heart rate of the observation group were higher (P<0.05). 4 weeks after treatment, the LVEF, CO and CI of the observation group were higher than those of the control group (P<0.05). 4 weeks after treatment, cAMP protein and PKA protein in peripheral blood mononuclear cells of the observation group were higher than those of the control group (P<0.05). There was no difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion Shenxian Shengmai oral liquid combined with trimetazidine in the treatment of BA patients can improve the therapeutic effect, promote the improvement of 24-hour dynamic electrocardiogram and cardiac function indexes, and its main mechanism may be related to the regulation of cAMP / PKA signal pathway related protein expression. |