| Objective: To investigate the efficacy of Naoxintong capsule combined with alteplase in the treatment of acute cerebral infarction (ACI), and to observe the effects of this treatment on coagulation function, hemorheology and cognitive function. Methods: 137 patients with ACI who were admitted to our hospital from June 2016 to December 2020 were selected. According to the random number table method, the patients were divided into control group and observation group, 68 cases in the control group were treated with alteplase, 69 cases in the observation group were treated with Naoxintong capsule combined with alteplase, both groups were treated for 10d. The clinical total effective rate of the two groups at 10d after treatment was compared. The changes of coagulation function, hemorheology and cognitive function of the two groups before treatment and 10d after treatment were observed. The liver and kidney function, blood routine and adverse drug reactions of the two groups were recorded. Results: There was significant difference in the total effective rate between the two groups (P<0.05). Compared with before treatment, the activated partial thromboplastin time (APTT), prothrombin time (PT), thrombin time (TT) in two groups at 10d after treatment were all prolonged, D-dimer (D-D), whole blood low shear viscosity, whole blood high shear viscosity, plasma viscosity and hematocrit all decreased (P<0.05), compared with the control group, the improvement of above indexes in the observation group was more significant (P<0.05). 10d after treatment, the National Institutes of Health Stroke Scale (NIHSS) scores were decreased in two groups compared with those before treatment, the scores of daily living ability scale (ADL) were all increased (P<0.05), compared with the control group, the improvement of above scores in the observation group was more significant (P<0.05). There was no abnormality in blood routine, liver and kidney function in the two groups, and no serious adverse reactions occurred. Compared with before treatment, all dimensions of quick cognitive screening?scale for elderly (QCST-E) scores in two groups were increased at 10d after treatment (P<0.05), and compared with the control group, the improvement in the observation group was more significant (P<0.05). Conclusion: On the basis of alteplase treatment combined with Naoxintong capsule in the treatment of ACI, it can improve the patients'' neurological function, improve the patients'' activities of daily living, and promote the improvement of coagulation function, hemorheology and cognitive function. |
