| Objective To investigate the effect of yougui decoction plus minus prescription combined with “GubenTongluo” acupuncture therapy on serum inflammatory factors and immune function of patients with rheumatoid arthritis. Methods According to the random table method, 105 cases of patients with rheumatoid arthritis admitted to our hospital from January 2018 to January 2020 were divided into control group (n=52) and the study group (n=53). The patients in the control group were treated with conventional western medicine treatment, while the patients in the study group were treated with yougui decoction plus minus prescription combined with “GubenTongluo” acupuncture therapy on the basis of the control group, the two groups were treated for 3 months. The clinical total effective rate of two groups of patients was counted. The DAS-28 integral and symptom and sign index integral were measured before and after treatment, at the same time, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), rheumatoid factor (RF), tumor necrosis factor-α (TNF-α), interleukin-1 (IL-1), interleukin-6 (IL-6) and peripheral blood CD3+, CD4+ and CD8+ levels were measured before and after treatment. Results The total effective rate of study group was significantly higher than that of the control group (P<0.05). The DAS-28 integral, symptom and sign index integral, CRP, RF, ESR, CD8+ and serum TNF-α, IL-1, IL-6 levels of the two groups were significantly lower than before treatment (P<0.05), the CD3+, CD4+ were significantly higher than before treatment (P<0.05). Meanwhile, the DAS-28 integral, symptom and sign index integral, CRP, RF, ESR, CD8+ and serum TNF-α, IL-1 and IL-6 levels of the study group were significantly lower than the control group (P<0.05), CD3+ and CD4+ were significantly higher than the control group (P<0.05). Conclusion The clinical curative effect of yougui decoction plus minus prescription combined with “GubenTongluo” acupuncture therapy for the treatment of rheumatoid arthritis is significantly, which can significantly reduce the clinical symptoms, inhibit inflammatory response and improve cellular immune function. |
