| Objective: To investigate and analyze the clinical value of magnetic resonance imaging (MRI) scanning combined with 4 items tumor markers in the diagnosis of primary liver cancer (PHC). Methods: 65 patients with PHC (liver cancer group) treated in our hospital from September 2017 to August 2019 were included in the study. Another 60 cases of benign liver disease were selected as the control group in our hospital at the same time. MRI features of the two groups were compared. In addition, serum alpha fetoprotein (AFP) and alpha-fetoprotein isoplast (AFP-L3), Golgi protein 73 (GP73) and phosphatidylinosano-3 (GPC-3) levels were detected and compared between the two groups. With pathological diagnosis as the gold standard, the effectiveness of different diagnostic methods in patients with PHC was analyzed. Results: MRI images of patients with PHC showed clear boundaries, similar to round or irregular lobules. The proportion of patients in the liver cancer group with low or slightly low T1WI signal intensity and equal signal intensity were higher than those in the control group, and the proportion of patients with high T2WI and DWI signal intensity were higher than those in the control group (all P<0.05).Pathological diagnosis was the gold standard, the sensitivity, specificity and accuracy of MRI combined with serum AFP, AFP-L3, GP73 and GPC-3 in PHC diagnosis were 95.24% (40/42), 95.65% (22/23) and 95.38% (62/65) respectively, were higher than 73.81% (31/42), 69.57% (16/23), 72.31% (47/65) in MRI diagnosis (P＜0.05), and 80.95% (34/42), 73.91% (17/23), 78.46% (51/65) in combined diagnosis of four serum tumor markers (P＜0.05). Conclusion: The levels of serum AFP, AFP-L3, GP73 and GPC-3 in PHC patients were increased, MRI scan combined with serum AFP, AFP-L3, GP73, GPC-3 can be used as effective means to diagnose PHC. |
