| Objective: To investigate the efficacy of ginseng polysaccharide injection combined with docetaxel and cisplatin (TP Regimen) in the treatment of advanced non-small cell lung cancer and its effects on helper T cell (Th) 1 / Th2 immune balance and serum tumor markers of patients. Methods: 80 patients with advanced NSCLC who were treated in our hospital from March 2019 to February 2021 were selected. According to the random number table method, they were randomly divided into control group (treated with TP Regimen, 40 cases) and observation group (treated with ginseng polysaccharide injection combined with TP Regimen, 40 cases). The efficacy, serum tumor markers, Th1 / Th2 immune balance index, quality of life and incidence of adverse reactions were compared between the two groups. Results: The objective remission rate and disease control rate of the observation group were 55.00% and 85.00% respectively, which were higher than 32.50% and 57.50% of the control group, the difference was statistically significant (P<0.05). 4 courses after treatment, the scores of each field of quality of life scale (FACT-L) of lung cancer patients in the two groups were higher than those before treatment, and the scores of the observation group were higher than those of the control group (P<0.05). 4 courses after treatment, the levels of tumor markers carbohydrate antigen 19-9 (CA19-9), cytokeratin-19 fragment (CYFRA21-1) and carcinoembryonic antigen (CEA) ) in the two groups decreased, and the observation group was lower than the control group (P<0.05). 4 courses after treatment, the level of serum γ-interferon (INF-γ) and interleukin-2 (IL-2) in the two groups were increased, and the observation group was higher than the control group (P<0.05). 4 courses after treatment, the levels of interleukin-4 (IL-4) and interleukin-5 (IL-5) in the two groups were decreased, and the observation group was lower than the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: The treatment of advanced NSCLC combined with ginseng polysaccharide injection on the basis of TP Chemotherapy can better reduce the level of serum tumor markers, control disease progression, regulate Th1 / Th2 immune balance and improve the quality of life of patients. |
