| Objective: To investigate the study on the relationship between the levels of β2-microglobulin (β2-MG), Granule protein precursor (PGRN) and Growth arrest gene 6 (Gas6) and disease severity and renal damage in patients with systemic lupus erythematosus. Methods: 105 patients with systemic lupus erythematosus who were treated in the rheumatology and immunology department of the second hospital of Hebei medical university from January 2017 to December 2020 were selected. According to the systemic lupus erythematosus disease activity index (SLEDAI), the patients were divided into 62 cases in the active phase group (SLEDAI ≥ 5 points) and 43 cases in the remission phase group (SLEDAI ≤ 4 points). Another 60 healthy volunteers who underwent physical examination in the second hospital of Hebei medical university in the same period were taken as the control group. serum β2-MG, PGRN, Gas6, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), serum complement, anti dsDNA antibody, blood urea nitrogen (BUN), blood creatinine (Scr), 24h urinary protein (24h UTP) were compared between the two groups, and analyze its correlation. Results: β2-MG, PGRN, ESR, CRP, anti dsDNA antibody, BUN, Scr, 24h UTP in the active phase group were higher than those of the remission phase group and control group. Gas6, serum complement C3、C4 were lower than those of the remission phase group and control group. β2-MG, PGRN, ESR, CRP, anti dsDNA antibody, BUN, Scr, 24h UTP in the remission phase group were higher than those of the control group. Gas6, serum complement C3、C4 were lower than those of the control group. The SLEDAI score in the active group was higher than that in the remission group（P＜0.05）.Pearson correlation analysis showed that: Serum of patients with systemic lupus erythematosus β2-MG and PGRN were positively correlated with SLEDAI, ESR, CRP, anti dsDNA, bun, SCR and 24h UTP, and negatively correlated with serum complement C3 and C4 (all P < 0.05). Gas6 level was negatively correlated with SLEDAI, ESR, CRP, anti dsDNA, bun, SCR and 24h UTP, and positively correlated with serum complement C3 and C4 (all P < 0.05). Conclusion: Serum of patients with systemic lupus erythematosus β The levels of 2-mg and PGRN increased abnormally and the level of Gas6 decreased abnormally, which is closely related to the degree of disease activity and renal damage. The detection of their levels may provide a reference for the evaluation of systemic lupus erythematosus disease. |
